Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D (Q24301560)

Phosphodiesterase 4B

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Phosphodiesterase 4D

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T cell receptor signaling pathway

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author name string

Daniel Peter

1

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S L Catherine Jin

2

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Marco Conti

3

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Armin Hatzelmann

4

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Christof Zitt

Knockdown of C-terminal Src kinase by siRNA-mediated RNA interference augments T cell receptor signaling in mature T cells

5

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language of work or name

English

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publication date

15 April 2007

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published in

Journal of Immunology

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volume

178

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page(s)

4820-31

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issue

8

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cites work

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In vitro PKA phosphorylation-mediated human PDE4A4 activation

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Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

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Induction of phosphodiesterases 3B, 4A4, 4D1, 4D2, and 4D3 in Jurkat T-cells and in human peripheral blood T-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor agonists. Potential role in beta2-adrenoreceptor desensitization.

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