MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met (Q24301503)

Mucin 20, cell surface associated

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identical protein binding

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Epidermal growth factor receptor

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Hepatocyte growth factor

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Mucin 20

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Hepatocyte growth factor receptor

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Mitogen-activated protein kinase 3

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Mitogen-activated protein kinase 1

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author name string

Toshio Higuchi

1

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Takuya Orita

2

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Ken Katsuya

3

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Yoshiki Yamasaki

4

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Kiyotaka Akiyama

5

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Huiping Li

6

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Tadashi Yamamoto

7

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Yutaka Saito

8

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Motonao Nakamura

Molecular and Cellular Biology

9

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language of work or name

English

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publication date

September 2004

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published in

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volume

24

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issue

17

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page(s)

7456-68

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cites work

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Efficient selection for high-expression transfectants with a novel eukaryotic vector

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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Molecular Cloning, Genomic Structure, and Expression Analysis of MUC20, a Novel Mucin Protein, Up-regulated in Injured Kidney

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Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development

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Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM

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The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

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Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein

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The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin

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Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland

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Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase

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Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain

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A differentiation switch for genetically modified hepatocytes

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The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase

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12 December 2020

Hepatocyte growth factor accelerates recovery from acute ischemic renal injury in rats

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12 December 2020

Reciprocal balance of hepatocyte growth factor and transforming growth factor-beta 1 in renal fibrosis in mice

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12 December 2020

Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways

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12 December 2020

Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy

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12 December 2020

Insulin-like growth factor I, a unique calcium-dependent stimulator of 1,25-dihydroxyvitamin D3 production. Studies in cultured mouse kidney cells

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12 December 2020