Regulation of the VHL/HIF-1 pathway by DJ-1 (Q24298803)

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20 March 2020

title

Regulation of the VHL/HIF-1 pathway by DJ-1 (English)

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Hypoxia inducible factor 1 subunit alpha

20 March 2020

main subject

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Parkinsonism associated deglycase

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Von Hippel-Lindau tumor suppressor

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negative regulation of ubiquitin-protein transferase activity

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Parkinson disease (autosomal recessive, early onset) 7

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author

Maxime Rousseaux

5

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20 March 2020

Hossein Aleyasin

6

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20 March 2020

Daniel Figeys

12

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20 March 2020

David S Park

13

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20 March 2020

8

Steve Callaghan

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20 March 2020

9

Ruth S Slack

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20 March 2020

1

Mohammad Parsanejad

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20 March 2020

4

Isabella Irrcher

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20 March 2020

author name string

Yi Zhang

2

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20 March 2020

Dianbo Qu

3

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20 March 2020

Fatemeh Kamkar

7

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20 March 2020

Tak W Mak

10

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20 March 2020

Stephen Lee

11

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20 March 2020

language of work or name

English

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publication date

1 June 2014

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20 March 2020

published in

Journal of Neuroscience

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20 March 2020

volume

34

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20 March 2020

page(s)

8043-8050

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20 March 2020

issue

23

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

20 March 2020

cites work

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12 December 2020

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

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12 December 2020

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

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12 December 2020

DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor

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12 December 2020

Erythropoietin restores glutathione peroxidase activity in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine-induced neurotoxicity in C57BL mice and stimulates murine astroglial glutathione peroxidase production in vitro

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12 December 2020

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

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12 December 2020

VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia

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12 December 2020

von Hippel-Lindau disease

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12 December 2020

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

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12 December 2020

The DJ-1L166P mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes

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12 December 2020

DJ-1 has a role in antioxidative stress to prevent cell death

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12 December 2020

Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage.

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12 December 2020

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

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12 December 2020

Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer

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12 December 2020

Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities

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12 December 2020

Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways

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12 December 2020

Large-scale mapping of human protein-protein interactions by mass spectrometry

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12 December 2020

Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease.

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12 December 2020

The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage.

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12 December 2020

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

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12 December 2020

Commitment of 1-methyl-4-phenylpyrinidinium ion-induced neuronal cell death by proteasome-mediated degradation of p35 cyclin-dependent kinase 5 activator

1 reference

12 December 2020

Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease

1 reference

12 December 2020

DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.

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12 December 2020

Calpain plays a central role in 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in cerebellar granule neurons.

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12 December 2020

The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death.

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12 December 2020

TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains.

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12 December 2020

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

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12 December 2020

HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells

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12 December 2020

Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA

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12 December 2020

Expression analysis of dopaminergic neurons in Parkinson's disease and aging links transcriptional dysregulation of energy metabolism to cell death.

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12 December 2020

4-iodophenyl isothiocyanate: a neuroprotective compound.

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12 December 2020

Mitochondrial inhibitor models of Huntington's disease and Parkinson's disease induce zinc accumulation and are attenuated by inhibition of zinc neurotoxicity in vitro or in vivo

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12 December 2020

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

1 reference

12 December 2020

10.1523/JNEUROSCI.1244-13.2014

Identifiers

DOI

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