Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase (Q24298275)

Signal peptide peptidase like 3

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Histocompatibility minor 13

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protein homodimerization activity

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author name string

Andrew C Nyborg

1

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Thomas B Ladd

2

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Karen Jansen

3

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Thomas Kukar

4

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Todd E Golde

Notch signaling: from the outside in

5

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language of work or name

English

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publication date

August 2006

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published in

FASEB Journal

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volume

20

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issue

10

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page(s)

1671-9

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cites work

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

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A new technique for the assay of infectivity of human adenovirus 5 DNA

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Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes

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https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity

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https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

On the mechanism of SPP-catalysed intramembrane proteolysis; conformational control of peptide bond hydrolysis in the plane of the membrane

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https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

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https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

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https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?

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https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs

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https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II.

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https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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Novel class of polytopic proteins with domains associated with putative protease activity

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https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Genome sequence of the human malaria parasite Plasmodium falciparum

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https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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The role of presenilin cofactors in the gamma-secretase complex

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https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

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https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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Reconstitution of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Intramembrane proteolysis and post-targeting functions of signal peptides

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

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https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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p38 Mitogen-activated protein kinase mediates the transcriptional induction of the atrial natriuretic factor gene through a serum response element. A potential role for the transcription factor ATF6.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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Novel approaches to tackling malarial drug resistance using yeast

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Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria.

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Identification of a novel family of presenilin homologues

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Identification of signal peptide peptidase, a presenilin-type aspartic protease

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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Parasitology. Drugs to combat tropical protozoan parasites

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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Intramembrane proteolysis and endoplasmic reticulum retention of hepatitis C virus core protein

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

7 January 2021

Intramembrane proteolysis by presenilin and presenilin-like proteases

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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Protease inhibitors as potential disease-modifying therapeutics for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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Drosophila signal peptide peptidase is an essential protease for larval development

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes

1 reference

https://api.crossref.org/works/10.1096%2FFJ.06-5762COM

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