LAPTM4B: a novel cancer-associated gene motivates multidrug resistance through efflux and activating PI3K/AKT signaling (Q24296238)

1

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X H Wei

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Y P Pan

3

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H C Li

4

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H Yang

5

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Q H He

6

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Y Pang

7

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Y Shan

8

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F X Xiong

9

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G Z Shao

10

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R L Zhou

Mechanisms of cancer drug resistance

11

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language of work or name

English

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publication date

28 October 2010

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published in

Oncogene

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volume

29

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page(s)

5785-95

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issue

43

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cites work

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LY294,002, a specific inhibitor of PI3K/Akt kinase pathway, antagonizes P-glycoprotein-mediated multidrug resistance

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Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway

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Actin disruption inhibits endosomal traffic of P-glycoprotein-EGFP and resistance to daunorubicin accumulation

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A mammalian lysosomal membrane protein confers multidrug resistance upon expression in Saccharomyces cerevisiae.

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The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression

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HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.

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Resistance mechanisms associated with altered intracellular distribution of anticancer agents.

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Phosphatidylinositol 3'-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells.

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Structure analysis and expressions of a novel tetratransmembrane protein, lysosoma-associated protein transmembrane 4 beta associated with hepatocellular carcinoma

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LAPTM4B-35, a novel tetratransmembrane protein and its PPRP motif play critical roles in proliferation and metastatic potential of hepatocellular carcinoma cells

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Differential gene expression in pituitary adenomas by oligonucleotide array analysis

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Expression of lysosome-associated protein transmembrane 4B-35 in cancer and its correlation with the differentiation status of hepatocellular carcinoma

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Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma

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Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts

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Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal

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An acid phosphatase assay for quantifying the growth of adherent and nonadherent cells

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Overexpression of LAPTM4B-35 promotes growth and metastasis of hepatocellular carcinoma in vitro and in vivo

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Elevated phosphatidylinositol 3-kinase activation and its clinicopathological significance in cervical cancer

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Expression of LAPTM4B-35: a novel marker of progression, invasiveness and poor prognosis of extrahepatic cholangiocarcinoma

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A chemical strategy to manipulate the intracellular localization of drugs in resistant cancer cells

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PI3K/Akt inhibition modulates multidrug resistance and activates NF-kappaB in murine lymphoma cell lines.

31 March 2020

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Experimentally induced changes in the endocytic traffic of P-glycoprotein alter drug resistance of cancer cells

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LAPTM4B-35 overexpression is a risk factor for tumor recurrence and poor prognosis in hepatocellular carcinoma

31 March 2020

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Overexpression of LAPTM4B-35 closely correlated with clinicopathological features and post-resectional survival of gallbladder carcinoma

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2010.303

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

991229

1017033237

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991229

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference