Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice (Q24295254)

protein O-linked glycosylation

GOA release 2020-03-11

1 reference

Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

Gunnar C Hansson

15

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author name string

Jianxin Fu

1

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Bo Wei

2

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Tao Wen

3

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Malin E V Johansson

4

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Xiaowei Liu

5

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Emily Bradford

6

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Kristina A Thomsson

7

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Samuel McGee

8

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Lilah Mansour

9

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Maomeng Tong

10

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J Michael McDaniel

11

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Thomas J Sferra

12

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Jerrold R Turner

13

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Hong Chen

14

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Jonathan Braun

16

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Lijun Xia

Journal of Clinical Investigation

17

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language of work or name

English

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publication date

April 2011

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published in

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volume

121

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issue

4

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page(s)

1657-66

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cites work

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Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice

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19 March 2017

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Cloning and expression of human core 1 beta1,3-galactosyltransferase

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Mucins and inflammatory bowel disease

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A Nonsynonymous SNP in ATG16L1 Predisposes to Ileal Crohn’s Disease and Is Independent of CARD15 and IBD5

19 March 2017

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Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model

19 March 2017

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Assembly of asparagine-linked oligosaccharides

19 March 2017

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Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

19 March 2017

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The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

19 March 2017

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Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans

19 March 2017

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RAG-1-deficient mice have no mature B and T lymphocytes

19 March 2017

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7 April 2017

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The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions

7 April 2017

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Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection

7 April 2017

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Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa

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27 September 2017

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27 September 2017

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Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection.

27 September 2017

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Regulation of protein O-glycosylation by the endoplasmic reticulum-localized molecular chaperone Cosmc

27 September 2017

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Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc

27 September 2017

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27 September 2017

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Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans

27 September 2017

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The fundamental basis of inflammatory bowel disease

27 September 2017

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27 September 2017

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Mucosal epithelium in health and disease

27 September 2017

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Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota

27 September 2017

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The immunology of mucosal models of inflammation

27 September 2017

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27 September 2017

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Sulphation and secretion of the predominant secretory human colonic mucin MUC2 in ulcerative colitis

27 September 2017

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Composition of human colonic mucin. Selective alteration in inflammatory bowel disease

27 September 2017

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Colonic mucus and ulcerative colitis

27 September 2017

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Altered expression of mucins throughout the colon in ulcerative colitis

30 May 2018

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Protein glycosylation: chaperone mutation in Tn syndrome

30 May 2018

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Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine.

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Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor.

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Alterations in mucosal content of colonic glycoconjugates in inflammatory bowel disease defined by monoclonal antibodies

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