PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development (Q24295182)

Signal transducer and activator of transcription 5A

1 reference

Cyclin D1

1 reference

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

1 reference

author

Christopher J Ormandy

5

Christopher J

Ormandy

Christopher J Ormandy

1 reference

20 October 2023

Chi-Bun Chan

1

Chi-Bun

Chan

1 reference

20 October 2023

Xia Liu

2

Xia

Liu

1 reference

20 October 2023

Michael A Ensslin

3

Michael A

Ensslin

1 reference

20 October 2023

Dirck L Dillehay

4

Dirck L

Dillehay

1 reference

20 October 2023

Philip Sohn

6

Philip

Sohn

1 reference

20 October 2023

Rosa Serra

7

Rosa

Serra

1 reference

20 October 2023

Keqiang Ye

8

Keqiang

Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B

Ye

1 reference

20 October 2023

language of work or name

English

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publication date

3 March 2010

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published in

The EMBO Journal

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volume

29

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issue

5

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page(s)

956-68

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cites work

1 reference

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Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse

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Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium

19 March 2017

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The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

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What can we learn from rodents about prolactin in humans?

27 September 2017

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Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways.

27 September 2017

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The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells

27 September 2017

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PIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death

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Alveolar and lactogenic differentiation

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The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium

27 September 2017

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Prolactin signals via Stat5 and Oct-1 to the proximal cyclin D1 promoter

27 September 2017

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27 September 2017

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PIKE/nuclear PI 3-kinase signaling mediates the antiapoptotic actions of NGF in the nucleus

27 September 2017

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27 September 2017

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Hormonal regulation of mammary differentiation and milk secretion

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27 September 2017

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Signaling pathways in mammary gland development.

27 September 2017

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IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line

27 September 2017

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C/EBPbeta, but not C/EBPalpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland.

27 September 2017

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The C/EBPbeta transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland

27 September 2017

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27 September 2017

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Activation of receptor-associated tyrosine kinase JAK2 by prolactin

27 September 2017

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Stat5a is mandatory for adult mammary gland development and lactogenesis.

27 September 2017

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Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation.

30 May 2018

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30 May 2018

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Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

30 May 2018

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PRL activates the cyclin D1 promoter via the Jak2/Stat pathway.

30 May 2018

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Prolactin activates Ras via signaling proteins SHC, growth factor receptor bound 2, and son of sevenless.

21 January 2018

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Transcriptional and spatiotemporal regulation of prolactin receptor mRNA and cooperativity with progesterone receptor function during ductal branch growth in the mammary gland

21 January 2018

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Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5.

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