Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif (Q24293524)

1

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Donna M Berry

2

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Jonathan S Maltzman

3

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Jacob Shabason

4

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Monica Raina

5

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Gary A Koretzky

6

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C Jane McGlade

Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT

7

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language of work or name

English

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publication date

7 February 2007

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published in

The EMBO Journal

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volume

26

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issue

3

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page(s)

678-89

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cites work

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SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity

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Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1

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Construction of an SH2 domain-binding site with mixed specificity

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Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain

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Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76

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Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide: a novel mode of peptide recognition

19 March 2017

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Protein-protein interaction affinity plays a crucial role in controlling the Sho1p-mediated signal transduction pathway in yeast

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Optimization of specificity in a cellular protein interaction network by negative selection

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Mona/Gads SH3C binding to hematopoietic progenitor kinase 1 (HPK1) combines an atypical SH3 binding motif, R/KXXK, with a classical PXXP motif embedded in a polyproline type II (PPII) helix

19 March 2017

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A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling

19 March 2017

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The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif

19 March 2017

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Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes

19 March 2017

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A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP

19 March 2017

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The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

19 March 2017

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Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc

19 March 2017

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Multiple Grb2-protein complexes in human cancer cells

19 March 2017

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RasGRP is essential for mouse thymocyte differentiation and TCR signaling

19 March 2017

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SH3 domains: complexity in moderation

19 March 2017

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The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains

7 April 2017

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7 April 2017

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7 January 2021

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Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction

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The Gads (GrpL) adaptor protein regulates T cell homeostasis

10 May 2017

1 reference

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Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences

27 September 2017

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Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems

27 September 2017

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Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function.

27 September 2017

1 reference

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The Structure and Function of Proline Recognition Domains

27 September 2017

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Adaptors as central mediators of signal transduction in immune cells

27 September 2017

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T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

27 September 2017

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Positive and negative regulation of T-cell activation by adaptor proteins

27 September 2017

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Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

27 September 2017

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Differential role of SLP-76 domains in T cell development and function

27 September 2017

1 reference

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The role of Gads in hematopoietic cell signalling.

27 September 2017

1 reference

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Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

27 September 2017

1 reference

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The adaptor protein Gads (Grb2-related adaptor downstream of Shc) is implicated in coupling hemopoietic progenitor kinase-1 to the activated TCR.

27 September 2017

1 reference

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Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.

27 September 2017

1 reference

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Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites

27 September 2017

1 reference

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Quantitative analysis of Grb2-Sos1 interaction: the N-terminal SH3 domain of Grb2 mediates affinity

27 September 2017

1 reference

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Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.

27 September 2017

1 reference

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Disruption of T cell signaling networks and development by Grb2 haploid insufficiency.

29 November 2018

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Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo

29 November 2018

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PubMed

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12 December 2020

inferred from PubMed ID database lookup

SLP-76 binding to p56lck: a role for SLP-76 in CD4-induced desensitization of the TCR/CD3 signaling complex

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17235283

12 December 2020

inferred from PubMed ID database lookup

Requirement for the SLP-76 adaptor GADS in T cell development

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17235283

12 December 2020