Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells (Q24290484)

regulation of natural killer cell mediated cytotoxicity

GOA release 2020-03-11

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GOA release 2020-03-11

author name string

K Jiang

1

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B Zhong

2

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D L Gilvary

3

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B C Corliss

4

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E Hong-Geller

5

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S Wei

6

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J Y Djeu

Functional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicity

7

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language of work or name

English

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publication date

November 2000

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published in

Nature Immunology

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volume

1

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page(s)

419-25

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issue

5

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cites work

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7 January 2021

Cutting edge: functional role for proline-rich tyrosine kinase 2 in NK cell-mediated natural cytotoxicity

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7 January 2021

The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing

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7 January 2021

Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: identification of perforin and granzyme B mobilization by functional ERK2.

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7 January 2021

T cell antigen receptor signal transduction

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7 January 2021

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

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7 January 2021

Direct tumor lysis by NK cells uses a Ras-independent mitogen-activated protein kinase signal pathway

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7 January 2021

Cdc42 and Rac stimulate exocytosis of secretory granules by activating the IP(3)/calcium pathway in RBL-2H3 mast cells

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7 January 2021

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

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7 January 2021

A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK

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7 January 2021

Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase gamma, a Rac guanosine exchange factor, and Rac.

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7 January 2021

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

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7 January 2021

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

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7 January 2021

Signaling through CD5 activates a pathway involving phosphatidylinositol 3-kinase, Vav, and Rac1 in human mature T lymphocytes

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7 January 2021

Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase

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7 January 2021

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

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7 January 2021

Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation

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7 January 2021

Inhibition of phosphatidylinositol 3-kinase blocks T cell antigen receptor/CD3-induced activation of the mitogen-activated kinase Erk2

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7 January 2021

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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7 January 2021

Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation

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7 January 2021

Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

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7 January 2021

Signals from the Ras, Rac, and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblasts

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7 January 2021

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

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7 January 2021

Reconstitution of T cell antigen receptor-induced Erk2 kinase activation in Lck-negative JCaM1 cells by Syk

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7 January 2021

Phosphorylation of the Grb2- and phosphatidylinositol 3-kinase p85-binding p36/38 by Syk in Lck-negative T cells

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7 January 2021

Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils

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7 January 2021

p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts

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7 January 2021

Identifiers

DOI

10.1038/80859

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Consolidated OpenCitations Corpus – April 2017

1675598

1675598

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference