Managing risks in drug discovery: reproducibility of published findings (Q24289508)

translational medical research

19 September 2019

1 reference

Naunyn-Schmiedeberg's Archives of Pharmacology

30 September 2020

adverse drug reaction

1 reference

23 November 2020

Thomas Wieland

2

0 references

author name string

Aimo Kannt

series ordinal

1

0 references

language of work or name

English

0 references

publication date

April 2016

0 references

1 April 2016

6 references

20 June 2019

22 June 2019

19 September 2019

24 June 2020

30 September 2020

23 November 2020

6 references

20 June 2019

22 June 2019

19 September 2019

24 June 2020

30 September 2020

23 November 2020

389

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page(s)

353-60

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issue

4

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copyright license

Creative Commons Attribution 4.0 International

6 references

20 June 2019

22 June 2019

19 September 2019

24 June 2020

30 September 2020

https://scigraph.springernature.com/pub.10.1007/s00210-016-1216-8

23 November 2020

0 references

0 references

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19 March 2017

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Translatability scoring in drug development: eight case studies

19 March 2017

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Do pressures to publish increase scientists' bias? An empirical support from US States Data

19 March 2017

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Publication bias in reports of animal stroke studies leads to major overstatement of efficacy

19 March 2017

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Why most published research findings are false

19 March 2017

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How to improve R&D productivity: the pharmaceutical industry's grand challenge

19 March 2017

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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

19 March 2017

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The Economics of Reproducibility in Preclinical Research

19 March 2017

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Believe it or not: how much can we rely on published data on potential drug targets?

19 March 2017

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Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

7 April 2017

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Why and how have drug discovery strategies in pharma changed? What are the new mindsets?

7 April 2017

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Neuroprotective therapies: Preclinical reproducibility is only part of the problem

27 September 2017

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Efficacy and safety of evolocumab in reducing lipids and cardiovascular events.

27 September 2017

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Efficacy and safety of alirocumab in reducing lipids and cardiovascular events

27 September 2017

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Cell Biology. Fixing problems with cell lines

27 September 2017

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Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

27 September 2017

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Increasing value and reducing waste in research design, conduct, and analysis

27 September 2017

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Clinical development success rates for investigational drugs

27 September 2017

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27 September 2017

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Research methods: Know when your numbers are significant

27 September 2017

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Third-generation sequencing techniques and applications to drug discovery

27 September 2017

1 reference

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Diagnosing the decline in pharmaceutical R&D efficiency

27 September 2017

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Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.

27 September 2017

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Historical overview of chemical library design

27 September 2017

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The future of high-throughput screening

27 September 2017

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Almost all articles on cancer prognostic markers report statistically significant results

27 September 2017

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A case study in misidentification of cancer cell lines: MCF-7/AdrR cells (re-designated NCI/ADR-RES) are derived from OVCAR-8 human ovarian carcinoma cells

27 September 2017

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Apolipoprotein B100 metabolism in autosomal-dominant hypercholesterolemia related to mutations in PCSK9.

27 September 2017

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Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia.

27 September 2017

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Negative results are disappearing from most disciplines and countries

27 September 2017

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Technology: The $1,000 genome

21 January 2018

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Improving R&D productivity

21 January 2018

1 reference

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Assessing the translatability of drug projects: what needs to be scored to predict success?

1 reference

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