The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells (Q23924111)

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journal article published in 2008

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English	The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells	journal article published in 2008

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scholarly article

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19 July 2017

Europe PubMed Central

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29 December 2019

The methoxychlor metabolite, HPTE, directly inhibits the catalytic activity of cholesterol side-chain cleavage (P450scc) in cultured rat ovarian cells (English)

2 references

12 July 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18065196%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

NIOSH Health Effects Laboratory Division

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HELD

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25 September 2023

2 references

19 July 2017

29 March 2020

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19 July 2017

exposure assessment

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29 March 2020

1 reference

29 March 2020

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29 March 2020

reproductive health

1 reference

29 March 2020

1 reference

29 March 2020

1

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29 December 2019

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Terence Meighan

3

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29 December 2019

Raymond C Derk

2

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29 December 2019

K Murali Krishna Rao

4

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29 December 2019

Eisuke P Murono

5

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29 December 2019

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25 October 2007

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29 December 2019

Reproductive Toxicology

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29 December 2019

25

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29 December 2019

1

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29 December 2019

67-75

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29 December 2019

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extramural research

1 reference

2 February 2024

The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function

1 reference

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The estrogen receptor beta subtype: a novel mediator of estrogen action in neuroendocrine systems

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Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells

1 reference

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Characteristics of the active oxygen in covalent binding of the pesticide methoxychlor to hepatic microsomal proteins.

1 reference

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Antifertility effect of methoxychlor in female rats: dose- and time-dependent blockade of pregnancy

1 reference

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Substrate-binding region of cytochrome P-450SCC (P-450 XIA1). Identification and primary structure of the cholesterol binding region in cytochrome P-450SCC.

1 reference

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Effects of methoxychlor on the reproductive system of the adult female mouse 1. Gross and histologic observations

1 reference

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Effects of methoxychlor on the reproductive system of the adult female mouse: 2. Ultrastructural observations

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Effect of methoxychlor on ovarian steroidogenesis: role in early pregnancy loss

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7 January 2021

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Mitochondrial specificity of the early steps in steroidogenesis

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7 January 2021

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The effects of the reported active metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane, on testosterone formation by cultured Leydig cells from young adult rats

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The reported active metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)- 1,1,1-trichloroethane, inhibits testosterone formation by cultured Leydig cells from neonatal rats

1 reference

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In vivo exposure of young adult male rats to methoxychlor reduces serum testosterone levels and ex vivo Leydig cell testosterone formation and cholesterol side-chain cleavage activity

1 reference

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Anti-progestogenic effect of flutamide on uterine expression of calbindin-D9k mRNA and protein in immature mice.

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The methoxychlor metabolite, 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane, inhibits steroidogenesis in rat ovarian granulosa cells in vitro

1 reference

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Decreased superovulation in adult mice following neonatal exposures to technical methoxychlor

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Comparative metabolism of methoxychlor, methiochlor, and DDT in mouse, insects, and in a model ecosystem

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The effect of raloxifene on the uterine weight response in immature mice exposed to 17beta-estradiol, 1,1,1-trichloro-2, 2-bis(p-chlorophenyl)ethane, and methoxychlor

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Comparative in vitro metabolism of methoxychlor in male and female rats: metabolism of demethylated methoxychlor metabolites by precision-cut rat liver slices

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7 January 2021

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Interactions of methoxychlor, methoxychlor base-soluble contaminant, and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane with rat uterine estrogen receptor

1 reference

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Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice.

1 reference

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Methoxychlor induces proliferation of the mouse ovarian surface epithelium

1 reference

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7 January 2021

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Effect of methoxychlor and estradiol on cytochrome p450 enzymes in the mouse ovarian surface epithelium

1 reference

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Methoxychlor inhibits growth and induces atresia of antral follicles through an oxidative stress pathway.

1 reference

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Synergism between granulosa and theca-interstitial cells in estrogen biosynthesis by gonadotropin-treated rat ovaries: studies on the two-cell, two-gonadotropin hypothesis using steroid antisera

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A metabolite of methoxychlor, 2,2-bis(p-hydroxyphenyl)-1,1, 1-trichloroethane, reduces testosterone biosynthesis in rat leydig cells through suppression of steady-state messenger ribonucleic acid levels of the cholesterol side-chain cleavage enzyme

1 reference

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The estrogenic and antiandrogenic pesticide methoxychlor alters the reproductive tract and behavior without affecting pituitary size or LH and prolactin secretion in male rats

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Hormonal Regulation of the Differentiation of Cultured Ovarian Granulosa Cells*

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Basal transcriptional activity and cyclic adenosine 3',5'-monophosphate responsiveness of the human cytochrome P450scc promoter transfected into MA-10 Leydig cells

1 reference

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Differential interaction of the methoxychlor metabolite 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane with estrogen receptors alpha and beta

1 reference

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Steroid Synthesis-Dependent, Oxygen-Mediated Damage of Mitochondrial and Microsomal Cytochrome P-450 Enzymes in Rat Leydig Cell Cultures*

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Identifiers

10.1016/J.REPROTOX.2007.10.007

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18065196%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18065196%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

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