advanced glycosylation end-product specific receptor (Q22683568)

Immunoglobulin-like domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Immunoglobulin subtype, protein family

1 reference

CD80-like, immunoglobulin C2-set, protein family

1 reference

Immunoglobulin subtype 2, protein family

1 reference

immunoglobulin-like domain, protein family

1 reference

Immunoglobulin/major histocompatibility complex, conserved site, protein family

1 reference

Immunoglobulin domain, protein family

1 reference

Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function

1 reference

13 November 2019

1 reference

13 November 2019

13 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

In vitro inhibition of transthyretin aggregate-induced cytotoxicity by full and peptide derived forms of the soluble receptor for advanced glycation end products (RAGE)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

Widespread macromolecular interaction perturbations in human genetic disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

Advanced glycation end product (AGE) receptor 1 suppresses cell oxidant stress and activation signaling via EGF receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

An immunogenic peptide in the A-box of HMGB1 protein reverses apoptosis-induced tolerance through RAGE receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

S100P promotes pancreatic cancer growth, survival, and invasion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

Interaction of the RAGE cytoplasmic domain with diaphanous-1 is required for ligand-stimulated cellular migration through activation of Rac1 and Cdc42

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

Structural and functional insights into RAGE activation by multimeric S100B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

S100B and S100A6 differentially modulate cell survival by interacting with distinct RAGE (receptor for advanced glycation end products) immunoglobulin domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

Advanced glycation end products increase endothelial permeability through the RAGE/Rho signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

identical protein binding

1 reference

9 May 2019

Structural insights into the oligomerization mode of the human receptor for advanced glycation end-products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

transmembrane signaling receptor activity

1 reference

9 May 2019

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

advanced glycation end-product binding

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q15109

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q15109

4 references

1 January 2018

The Cellular Phase of Alzheimer's Disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15109&geneProductId=UniProtKB:Q15109

1 January 2018

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15109&geneProductId=UniProtKB:Q15109

1 January 2018

Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15109&geneProductId=UniProtKB:Q15109

1 January 2018

A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15109&geneProductId=UniProtKB:Q15109

scavenger receptor activity

1 reference

9 May 2019

Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

advanced glycation end-product receptor activity

1 reference

9 May 2019

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

5 references

9 May 2019

The Cellular Phase of Alzheimer's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

protein-containing complex binding

1 reference

9 May 2019

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

integral component of membrane

cell component

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

integral component of plasma membrane

1 reference

3 January 2017

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q15109

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

1 reference

9 May 2019

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

NAS

apical plasma membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

1 reference

9 May 2019

Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

negative regulation of interleukin-10 production

biological process

1 reference

9 May 2019

HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

positive regulation of interleukin-12 production

1 reference

9 May 2019

Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

cell surface receptor signaling pathway

IMP

1 reference

9 May 2019

Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

1 reference

9 May 2019

RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

positive regulation of NF-kappaB transcription factor activity

1 reference

3 January 2017

Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q15109

positive regulation of dendritic cell differentiation

1 reference

9 May 2019

Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

IMP

innate immune response

1 reference

9 May 2019

RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides

inflammatory response

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

regulation of T cell mediated cytotoxicity

1 reference

9 May 2019

HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

regulation of CD4-positive, alpha-beta T cell activation

1 reference

9 May 2019

HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

positive regulation of activated T cell proliferation

1 reference

9 May 2019

Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

negative regulation of advanced glycation end-product receptor activity

IMP

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q15109

protein localization to membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

positive regulation of JUN kinase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

regulation of DNA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

induction of positive chemotaxis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

regulation of inflammatory response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

astrocyte development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

neuron projection development

1 reference

9 May 2019

Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

negative regulation of connective tissue replacement involved in inflammatory response wound healing

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

positive regulation of monocyte chemotactic protein-1 production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

positive regulation of protein phosphorylation

1 reference

9 May 2019

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

receptor-mediated endocytosis

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

1 reference

9 May 2019

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

glucose mediated signaling pathway

1 reference

9 May 2019

Regulation of RAGE splicing by hnRNP A1 and Tra2β-1 and its potential role in AD pathogenesis

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

positive regulation of heterotypic cell-cell adhesion

1 reference

9 May 2019

beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

3 references

9 May 2019

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

positive regulation of JNK cascade

1 reference

9 May 2019

Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

regulation of synaptic plasticity

3 references

9 May 2019

Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

Abeta-dependent Inhibition of LTP in different intracortical circuits of the visual cortex: the role of RAGE

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

positive regulation of NF-kappaB transcription factor activity

positive regulation of astrocyte activation

1 reference

9 May 2019

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

positive regulation of ERK1 and ERK2 cascade

1 reference

9 May 2019

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

regulation of spontaneous synaptic transmission

1 reference

9 May 2019

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

negative regulation of long-term synaptic potentiation

negative regulation of long-term synaptic depression

1 reference

9 May 2019

Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

positive regulation of p38MAPK cascade

1 reference

9 May 2019

Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

regulation of NIK/NF-kappaB signaling

1 reference

9 May 2019

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

positive regulation of NIK/NF-kappaB signaling

NAS

1 reference

9 May 2019

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

1 reference

9 May 2019

A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

positive regulation of microglial cell activation

4 references

9 May 2019

The Cellular Phase of Alzheimer's Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex

response to amyloid-beta

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

positive regulation of monocyte extravasation

1 reference

9 May 2019

beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15109

has part(s)

immunoglobulin domain

1 reference

immunoglobulin subtype 2

1 reference

immunoglobulin-like domain

1 reference

Immunoglobulin/major histocompatibility complex, conserved site

1 reference

CD80-like, immunoglobulin C2-set

1 reference

immunoglobulin subtype

1 reference

Identifiers

MeSH descriptor ID

D000067759

subject named as

Receptor for Advanced Glycation End Products

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30 May 2020

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13 November 2019

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9 August 2016

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9 August 2016

Transporter Classification Database ID

English

8.A.23.1.19

2 references

Transporter Classification database

retrieved

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata