Molybdenum cofactor synthesis 3 (Q22679898)

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mammalian protein found in Homo sapiens

molybdopterin synthase sulfurylase
adenylyltransferase and sulfurtransferase MOCS3
MOCS3
ubiquitin-like modifier activating enzyme 4
MPT synthase sulfurylase
molybdenum cofactor synthesis protein 3
UBA4, ubiquitin-activating enzyme E1 homolog

Language	Label	Description	Also known as
English	Molybdenum cofactor synthesis 3	mammalian protein found in Homo sapiens	molybdopterin synthase sulfurylase adenylyltransferase and sulfurtransferase MOCS3 MOCS3 ubiquitin-like modifier activating enzyme 4 MPT synthase sulfurylase molybdenum cofactor synthesis protein 3 UBA4, ubiquitin-activating enzyme E1 homolog

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

Adenylyltransferase and sulfurtransferase MOCS3/Uba4

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95396

ubiquitin-activating enzyme

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95396

Rhodanese-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95396

THIF-type NAD/FAD binding fold, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rhodanese-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

thiosulfate sulfurtransferase activity

determination method

3 references

16 July 2018

Site-directed mutagenesis of the active site loop of the rhodanese-like domain of the human molybdopterin synthase sulfurase MOCS3. Major differences in substrate specificity between eukaryotic and bacterial homologs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95396&geneProductId=UniProtKB:O95396

determination method

16 July 2018

Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95396&geneProductId=UniProtKB:O95396

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95396&geneProductId=UniProtKB:O95396

determination method

molybdopterin-synthase sulfurtransferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

URM1 activating enzyme activity

determination method

1 reference

16 July 2018

A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95396&geneProductId=UniProtKB:O95396

determination method

protein binding

determination method

catalytic activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

ubiquitin-like modifier activating enzyme activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

molybdopterin-synthase adenylyltransferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

nucleotidyltransferase activity

determination method

1 reference

24 April 2018

A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95396&geneProductId=UniProtKB:O95396

determination method

sulfurtransferase activity

determination method

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95396&geneProductId=UniProtKB:O95396

determination method

24 April 2018

A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95396&geneProductId=UniProtKB:O95396

determination method

24 April 2018

Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95396&geneProductId=UniProtKB:O95396

determination method

24 April 2018

A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95396&geneProductId=UniProtKB:O95396

determination method

sulfurtransferase activity

determination method

5 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95396&geneProductId=UniProtKB:O95396

determination method

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95396&geneProductId=UniProtKB:O95396

determination method

10 September 2018

Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95396&geneProductId=UniProtKB:O95396

determination method

10 September 2018

A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95396&geneProductId=UniProtKB:O95396

determination method

10 September 2018

A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95396&geneProductId=UniProtKB:O95396

determination method

thiosulfate sulfurtransferase activity

determination method

4 references

8 April 2019

Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

8 April 2019

Site-directed mutagenesis of the active site loop of the rhodanese-like domain of the human molybdopterin synthase sulfurase MOCS3. Major differences in substrate specificity between eukaryotic and bacterial homologs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

nucleotidyltransferase activity

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

8 April 2019

A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

sulfurtransferase activity

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

8 April 2019

Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

8 April 2019

A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

8 April 2019

A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

determination method

1 reference

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95396&geneProductId=UniProtKB:O95396

determination method

determination method

3 references

biological process

molybdopterin cofactor biosynthetic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

tRNA processing

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

tRNA wobble uridine modification

determination method

1 reference

24 April 2018

A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95396&geneProductId=UniProtKB:O95396

determination method

tRNA thio-modification

determination method

1 reference

24 April 2018

A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O95396&geneProductId=UniProtKB:O95396

determination method

protein urmylation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95396

determination method

Rhodanese-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95396

THIF-type NAD/FAD binding fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O95396

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000244051

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000244051

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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