leptin (Q223739)

http://www.ebi.ac.uk/interpro/protein/P41159

four-helical cytokine-like, core

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41159

video

Warum das Hormon Leptin uns satt macht (CC BY 4.0).webm
1 min 6 s, 1,280 × 720; 8.45 MB

language of work or name

0 references

1 reference

13 November 2019

1 reference

13 November 2019

signaling receptor binding

3 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

cell component

cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

extracellular region

TAS

extracellular space

A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

HUGO Gene Nomenclature Committee

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of protein phosphorylation

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

response to dietary excess

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

cellular response to retinoic acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of developmental growth

1 reference

8 April 2019

Milk intake and feeding behavior in the first week of life and its relationship to cord blood ghrelin, leptin, and insulin concentrations

GOA

curator

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

negative regulation of glucagon secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

placenta development

1 reference

8 April 2019

Milk intake and feeding behavior in the first week of life and its relationship to cord blood ghrelin, leptin, and insulin concentrations

GOA

curator

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

cardiac muscle hypertrophy

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of angiogenesis

1 reference

8 April 2019

Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

prostaglandin secretion

1 reference

8 April 2019

Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of intestinal cholesterol absorption

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of reactive oxygen species metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

central nervous system neuron development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

circadian rhythm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of ion transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

angiogenesis

glucose metabolic process

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of peroxisome proliferator activated receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of hepatic stellate cell activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of endothelial cell proliferation

1 reference

8 April 2019

Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

intestinal absorption

1 reference

8 April 2019

Leptin Inhibits Glucose Intestinal Absorption via PKC, p38MAPK, PI3K and MEK/ERK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

response to ethanol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of p38MAPK cascade

1 reference

24 April 2018

Leptin Inhibits Glucose Intestinal Absorption via PKC, p38MAPK, PI3K and MEK/ERK

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41159&geneProductId=UniProtKB:P41159

negative regulation of metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

negative regulation of vasoconstriction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

glucose homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of insulin secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of steroid biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

insulin secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of natural killer cell activation

1 reference

8 April 2019

Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of fat cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

response to vitamin E

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

response to nutrient levels

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

bone mineralization involved in bone maturation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of T cell proliferation

1 reference

8 April 2019

Leptin modulates autophagy in human CD4+CD25- conventional T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of protein import into nucleus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

fatty acid beta-oxidation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

hormone metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of MAPK cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

8 April 2019

Leptin Inhibits Glucose Intestinal Absorption via PKC, p38MAPK, PI3K and MEK/ERK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of TOR signaling

1 reference

24 April 2018

Leptin modulates autophagy in human CD4+CD25- conventional T cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41159&geneProductId=UniProtKB:P41159

cellular response to L-ascorbic acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

ovulation from ovarian follicle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

activation of protein kinase C activity

1 reference

24 April 2018

Leptin Inhibits Glucose Intestinal Absorption via PKC, p38MAPK, PI3K and MEK/ERK

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41159&geneProductId=UniProtKB:P41159

negative regulation of cartilage development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

response to nutrient

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

negative regulation of glutamine transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

bile acid metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

female pregnancy

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

negative regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

cholesterol metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of follicle-stimulating hormone secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of protein localization to nucleus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of blood pressure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

negative regulation of glucose import

1 reference

8 April 2019

Leptin Inhibits Glucose Intestinal Absorption via PKC, p38MAPK, PI3K and MEK/ERK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

leukocyte tethering or rolling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

negative regulation of lipid storage

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

adipose tissue development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of insulin receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of receptor signaling pathway via JAK-STAT

glycerol biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of luteinizing hormone secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

fatty acid catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of gluconeogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

response to estradiol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

intracellular signal transduction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

response to hypoxia

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of natural killer cell proliferation

1 reference

8 April 2019

Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

eating behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of cytokine production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of cytokine production involved in inflammatory response

1 reference

8 April 2019

Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

response to activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

cellular response to leptin stimulus

1 reference

8 April 2019

leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of natural killer cell mediated cytotoxicity

1 reference

8 April 2019

Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of fat cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of lipoprotein lipid oxidation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of phosphatidylinositol 3-kinase signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41159&geneProductId=UniProtKB:P41159

3 references

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41159&geneProductId=UniProtKB:P41159

24 April 2018

Leptin Inhibits Glucose Intestinal Absorption via PKC, p38MAPK, PI3K and MEK/ERK

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41159&geneProductId=UniProtKB:P41159

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

1 reference

8 April 2019

negative regulation of appetite by leptin-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

interleukin-12 production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of tumor necrosis factor production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

interleukin-6 production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

phagocytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

energy reserve metabolic process

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of tyrosine phosphorylation of STAT protein

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

determination of adult lifespan

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of phosphatidylinositol 3-kinase signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

8 April 2019

Leptin Inhibits Glucose Intestinal Absorption via PKC, p38MAPK, PI3K and MEK/ERK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

positive regulation of receptor signaling pathway via JAK-STAT

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

8 April 2019

leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of lipid biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

aorta development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

regulation of catalytic activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159

elastin metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41159