Neuroscience in the era of functional genomics and systems biology (Q22337243)

Europe PubMed Central

title

Neuroscience in the era of functional genomics and systems biology (English)

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1 reference

1

Daniel H. Geschwind

Daniel H.

Geschwind

1 reference

Dimensions Publication ID

Dimensions

7 February 2023

Genevieve Konopka

2

Genevieve

Konopka

1 reference

Dimensions Publication ID

Dimensions

1049203191

The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice

7 February 2023

language of work or name

English

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publication date

15 October 2009

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published in

Nature

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volume

461

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issue

7266

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page(s)

908-15

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cites work

1 reference

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19 March 2017

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Variations in DNA elucidate molecular networks that cause disease

19 March 2017

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Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways

19 March 2017

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An evaluation of human protein-protein interaction data in the public domain

19 March 2017

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A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

6 April 2017

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A neutral model of transcriptome evolution

19 March 2017

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Genome-wide atlas of gene expression in the adult mouse brain

19 March 2017

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Network biology: understanding the cell's functional organization

19 March 2017

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Human Proteinpedia enables sharing of human protein data

19 March 2017

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Molecular anatomy of a trafficking organelle

19 March 2017

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Molecular taxonomy of major neuronal classes in the adult mouse forebrain

19 March 2017

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Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo

19 March 2017

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Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex

19 March 2017

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Proteomic analysis of NMDA receptor-adhesion protein signaling complexes

19 March 2017

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Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins

19 March 2017

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Phenomics: the systematic study of phenotypes on a genome-wide scale

19 March 2017

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THG-1pit moves to nucleus at the onset of cerebellar granule neurons apoptosis

19 March 2017

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Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling

19 March 2017

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Complex brain networks: graph theoretical analysis of structural and functional systems

19 March 2017

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A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function

7 April 2017

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The large-scale organization of metabolic networks

7 April 2017

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Functional and evolutionary insights into human brain development through global transcriptome analysis

7 April 2017

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A translational profiling approach for the molecular characterization of CNS cell types

7 April 2017

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A general framework for weighted gene co-expression network analysis

7 April 2017

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A gene expression atlas of the central nervous system based on bacterial artificial chromosomes

7 April 2017

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A gene-coexpression network for global discovery of conserved genetic modules

7 April 2017

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Gene-network analysis identifies susceptibility genes related to glycobiology in autism

7 April 2017

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Intra- and inter-individual genetic differences in gene expression

27 September 2017

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Genetic control of human brain transcript expression in Alzheimer disease

27 September 2017

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PIPs: human protein-protein interaction prediction database

27 September 2017

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G2Cdb: the Genes to Cognition database.

27 September 2017

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ConsensusPathDB--a database for integrating human functional interaction networks

27 September 2017

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Functional organization of the transcriptome in human brain

27 September 2017

1 reference

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Evolutionary expansion and anatomical specialization of synapse proteome complexity.

27 September 2017

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Genetic-linkage mapping of complex hereditary disorders to a whole-genome molecular-interaction network

27 September 2017

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A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging

27 September 2017

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Quantitative analysis of synaptic phosphorylation and protein expression

27 September 2017

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Probing genetic overlap among complex human phenotypes.

27 September 2017

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Celsius: a community resource for Affymetrix microarray data

27 September 2017

1 reference

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Comparison of hybridization-based and sequencing-based gene expression technologies on biological replicates.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Network structure of cerebral cortex shapes functional connectivity on multiple time scales

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

A high-quality catalog of the Drosophila melanogaster proteome

27 September 2017

1 reference

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Network activity-independent coordinated gene expression program for synapse assembly.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

DNA variation and brain region-specific expression profiles exhibit different relationships between inbred mouse strains: implications for eQTL mapping studies.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Conservation and evolution of gene coexpression networks in human and chimpanzee brains

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Imitating manual curation of text-mined facts in biomedicine

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Probing the transcriptome of neuronal cell types

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Integrating genetic and network analysis to characterize genes related to mouse weight

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Microarrays and the microscope: balancing throughput with resolution

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

High throughput protein expression screening in the nervous system--needs and limitations.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

A mammalian organelle map by protein correlation profiling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Mapping determinants of human gene expression by regional and genome-wide association

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

A unique gene expression signature discriminates familial Alzheimer's disease mutation carriers from their wild-type siblings

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Adult mouse brain gene expression patterns bear an embryologic imprint

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Human brain evolution: insights from microarrays

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Systems biology and new technologies enable predictive and preventative medicine.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

DNA-microarray analysis of brain cancer: molecular classification for therapy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Coexpression analysis of human genes across many microarray data sets

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Progress in the use of microarray technology to study the neurobiology of disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

WebQTL: web-based complex trait analysis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

GeneWays: a system for extracting, analyzing, visualizing, and integrating molecular pathway data

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Extensive and divergent effects of sleep and wakefulness on brain gene expression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Sharing gene expression data: an array of options

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Regional and strain-specific gene expression mapping in the adult mouse brain

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Mice, microarrays, and the genetic diversity of the brain

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Transcriptional and electrophysiological maturation of neocortical fast-spiking GABAergic interneurons

27 September 2017

1 reference

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Structure and complexity of a bacterial transcriptome.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Application of a translational profiling approach for the comparative analysis of CNS cell types

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

The organization of the transcriptional network in specific neuronal classes.

30 May 2018

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Crossref

https://api.crossref.org/works/10.1038%2FNATURE08537

Limitations and possibilities of small RNA digital gene expression profiling.

21 January 2018

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Genomic anatomy of the hippocampus.

29 November 2018

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Searching the protein interaction space through the MINT database.

29 November 2018

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The evolution of the arcuate fasciculus revealed with comparative DTI.

29 November 2018

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A survey of genetic human cortical gene expression

29 November 2018

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ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

Blood genomic responses differ after stroke, seizures, hypoglycemia, and hypoxia: blood genomic fingerprints of disease

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3645852

29 November 2018

Identifiers

DOI

10.1038/NATURE08537

1 reference

Dimensions Publication ID

1391648

1049203191

0 references

1391648

1 reference

1 reference

1 reference