Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging (Q22252371)

PubMed

PubMed publication ID

22019846

29 March 2023

Diane C. Cabelof

series ordinal

2

author given names

Diane C

author last names

Cabelof

1 reference

PubMed

PubMed publication ID

22019846

Mechanisms of Ageing and Development

29 March 2023

language of work or name

English

0 references

publication date

April 2012

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published in

0 references

volume

133

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issue

4

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page(s)

133-137

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cites work

Mortality and cancer incidence among individuals with Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Down's syndrome is associated with increased 8,12-iso-iPF2alpha-VI levels: evidence for enhanced lipid peroxidation in vivo

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Hematologic abnormalities in children with Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Updated national birth prevalence estimates for selected birth defects in the United States, 2004-2006

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Aneuploidy induced in lymphocytes of parents of trisomic 21 children.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Early glycoxidation damage in brains from Down's syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Chromosomal radiosensitivity of Down syndrome lymphocytes at different stages of the cell cycle.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Down syndrome and leukemia: unusual clinical aspects and unexpected methotrexate sensitivity

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Human DNA Polymerase-beta Promoter: Phorbol Ester Activation Is Mediated through the cAMP Response Element and cAMP-Response-Element-Binding Protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Multiple evidence for an early age pro-oxidant state in Down Syndrome patients

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Protein carbonyls as a biomarker of foetal-neonatal hypoxic stress

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Early oxidative stress in amniotic fluid of pregnancies with Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Aging and base excision repair: in need of a comprehensive approach

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Folate deficiency increases mtDNA and D-1 mtDNA deletion in aged brain of mice lacking uracil-DNA glycosylase.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Folate deficiency regulates expression of DNA polymerase β in response to oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

The role of oxidative damage and stress in aging.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Shorter telomeres may indicate dementia status in older individuals with Down syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Systemic pathology in aged mouse models of Down's syndrome and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Attenuation of DNA polymerase beta-dependent base excision repair and increased DMS-induced mutagenicity in aged mice

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

The effect of folate deficiency on the hprt mutational spectrum in Chinese hamster ovary cells treated with monofunctional alkylating agents

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Trisomy 21 and accelerated aging: DNA-repair parameters in peripheral lymphocytes of Down's syndrome patients.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Biological ages of adult men and women with Down's syndrome and its changes with aging.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Health conditions associated with aging and end of life of adults with Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Genomic instability in Down syndrome and Fanconi anemia assessed by micronucleus analysis and single-cell gel electrophoresis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Biomarkers of oxidative stress are significantly elevated in Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Cognitive deficits and associated neurological complications in individuals with Down's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Mortality and cancer incidence in persons with Down's syndrome, their parents and siblings

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in rat colon

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Increased uracil misincorporation in lymphocytes from folate-deficient rats

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

The ATF/CREB transcription factor-binding site in the polymerase beta promoter mediates the positive effect of N-methyl-N'-nitro-N-nitrosoguanidine on transcription

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Imbalanced base excision repair in response to folate deficiency is accelerated by polymerase beta haploinsufficiency

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Homocysteine metabolism in children with Down syndrome: in vitro modulation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Induction of DNA polymerase beta-dependent base excision repair in response to oxidative stress in vivo

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Lifespan and incidence of cancer and other diseases in selected long-lived inbred mice and their F 1 hybrids

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

SIRT1 deacetylates APE1 and regulates cellular base excision repair

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Methotrexate Accumulation and Folate Depletion in Cells as a Possible Mechanism of Chronic Toxicity to the Drug

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

In vivo folic acid supplementation partially corrects in vitro methotrexate toxicity in patients with Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

MNB/DYRK1A as a multiple regulator of neuronal development

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

The role of DYRK1A in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

MicroRNA responses to cellular stress.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

DNA polymerase activity as an index of lymphocyte stimulation: studies in Down's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

The incidence of mongolism in the general population

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Free radical theory of aging: an update: increasing the functional life span

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Decreased repair of x-ray induced DNA single-strand breaks in lymphocytes in Down's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

DNA polymerase beta gene expression: the promoter activator CREB-1 is upregulated in Chinese hamster ovary cells by DNA alkylating agent-induced stress

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Hematological studies in children with Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021

Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia

1 reference

https://api.crossref.org/works/10.1016%2FJ.MAD.2011.10.001

7 January 2021