Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions (Q22010220)

2

W

Luo

1 reference

7 February 2023

M Geyer

3

M

Geyer

1 reference

7 February 2023

A S Alberts

4

A S

Alberts

1 reference

7 February 2023

B M Peterlin

5

B M

Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis

Peterlin

1 reference

7 February 2023

language of work or name

English

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publication date

June 1999

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published in

Molecular Cell

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volume

3

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page(s)

729-39

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issue

6

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cites work

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Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1.

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The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling

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RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef

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HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization

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SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.

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Human immunodeficiency virus type 1 genome activation induced by human T-cell leukemia virus type 1 Tax protein is through cooperation of NF-kappaB and Tat.

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The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation.

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The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

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Viral manipulations of the actin cytoskeleton.

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gag, vif, and nef genes contribute to the homologous viral interference induced by a nonproducer human immunodeficiency virus type 1 (HIV-1) variant: identification of novel HIV-1-inhibiting viral protein mutants

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Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells

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7 January 2021

Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

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Vav links antigen-receptor signaling to the actin cytoskeleton.

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Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation

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7 January 2021

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

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7 January 2021

Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.

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Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation

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The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes

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7 January 2021

The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase

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Rho GTPases and the actin cytoskeleton

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7 January 2021

Lck regulates Vav activation of members of the Rho family of GTPases

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7 January 2021

Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice

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7 January 2021

Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans

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7 January 2021

The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

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Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

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Interaction of invasive bacteria with host signaling pathways

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7 January 2021

Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes

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7 January 2021

Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity

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Importance of the nef gene for maintenance of high virus loads and for development of AIDS

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7 January 2021

Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells

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7 January 2021

Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

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7 January 2021

Vav regulates peptide-specific apoptosis in thymocytes

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7 January 2021

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein

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7 January 2021

Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain

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7 January 2021

Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules

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7 January 2021

CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1.

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Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4

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Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase gamma, a Rac guanosine exchange factor, and Rac.

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7 January 2021

SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase

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7 January 2021

Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

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7 January 2021

Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

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7 January 2021

Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases

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7 January 2021

Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes

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7 January 2021

The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.

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The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes

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7 January 2021

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

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7 January 2021

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

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7 January 2021

Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes

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7 January 2021

A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity

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7 January 2021

Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques

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7 January 2021

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

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7 January 2021

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

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7 January 2021

Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene

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7 January 2021

HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis

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7 January 2021

Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation

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7 January 2021

A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

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7 January 2021