Structural and biochemical evaluation of the interaction of the phosphatidylinositol 3-kinase p85alpha Src homology 2 domains with phosphoinositides and inositol polyphosphates (Q22010069)

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English	Structural and biochemical evaluation of the interaction of the phosphatidylinositol 3-kinase p85alpha Src homology 2 domains with phosphoinositides and inositol polyphosphates	scientific article

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8 December 2019

Structural and biochemical evaluation of the interaction of the phosphatidylinositol 3-kinase p85alpha Src homology 2 domains with phosphoinositides and inositol polyphosphates (English)

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8 December 2019

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Paul C. Driscoll

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8 December 2019

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M J Bottomley

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1 May 1999

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8 December 2019

Journal of Biological Chemistry

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15678-15685

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8 December 2019

SH2 and SH3 domains

1 reference

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Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach

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Protein modules and signalling networks

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The assembly of signalling complexes by receptor tyrosine kinases

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Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

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Phosphatidylinositol 3-kinase

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PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

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Phosphoinositide 3-kinases: a conserved family of signal transducers

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Signalling through the lipid products of phosphoinositide-3-OH kinase

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

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Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

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Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

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Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

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Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate

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21 January 2018

Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase

1 reference

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21 January 2018

Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase

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21 January 2018

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

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21 January 2018

Phosphopeptide binding to the N-terminal SH2 domain of the p85 alpha subunit of PI 3'-kinase: a heteronuclear NMR study

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Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes

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A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains

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Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

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Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains

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Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts

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Lipid-Regulated Kinases: Some Common Themes at Last

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High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

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Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding

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Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins

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7 January 2021

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8 December 2019

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8 December 2019

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