The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy (Q22003869)

protein homodimerization activity

GOA release 2020-03-11

1 reference

Evolutionary relationships among pyridoxal-5'-phosphate-dependent enzymes. Regio-specific alpha, beta and gamma families

GOA release 2020-03-11

S B Renwick

1

S B

Renwick

1 reference

7 February 2023

K Snell

series ordinal

2

author given names

K

author last names

Snell

1 reference

7 February 2023

U Baumann

series ordinal

3

author given names

U

author last names

Baumann

1 reference

7 February 2023

language of work or name

English

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publication date

15 September 1998

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published in

Structure

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volume

6

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page(s)

1105-16

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issue

9

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cites work

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Enzymic imbalance in serine metabolism in rat hepatomas

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Effects of a triazine antifolate (NSC 127755) on serine hydroxymethyltransferase in myeloma cells in culture

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Crystal structure of human dihydrofolate reductase complexed with folate

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Atomic structure of thymidylate synthase: target for rational drug design

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Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site

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The methotrexate story: a paradigm for development of cancer chemotherapeutic agents.

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Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors

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Thymidylate synthase inhibition: a structure-based rationale for drug design

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Serine hydroxymethyltransferase: origin of substrate specificity

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The function of arginine 363 as the substrate carboxyl-binding site in Escherichia coli serine hydroxymethyltransferase.

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Structural studies on folding intermediates of serine hydroxymethyltransferase using fluorescence resonance energy transfer

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The Role of His-134, -147, and -150 Residues in Subunit Assembly, Cofactor Binding, and Catalysis of Sheep Liver Cytosolic Serine Hydroxymethyltransferase

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Diffraction grade crystals of Escherichia coli serine hydroxymethyltransferase

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Recognition of errors in three-dimensional structures of proteins

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Phi/psi-chology: Ramachandran revisited

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Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure

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Protein structure comparison by alignment of distance matrices

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Three-dimensional structure of tyrosine phenol-lyase

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Dialkylglycine decarboxylase structure: bifunctional active site and alkali metal sites

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Structural and mechanistic analysis of two refined crystal structures of the pyridoxal phosphate-dependent enzyme dialkylglycine decarboxylase

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X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase

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Crystallographic structure of a PLP-dependent ornithine decarboxylase from Lactobacillus 30a to 3.0 A resolution

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7 January 2021

Crystal structure analysis of omega-amino acid:pyruvate aminotransferase with a newly developed Weissenberg camera and an imaging plate using synchrotron radiation

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Crystal structure of the pyridoxal-5'-phosphate dependent cystathionine beta-lyase from Escherichia coli at 1.83 A

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The anatomy and taxonomy of protein structure

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Importance of the amino terminus in maintenance of oligomeric structure of sheep liver cytosolic serine hydroxymethyltransferase.

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The mechanism of action of serine transhydroxymethylase

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Lysine 258 in aspartate aminotransferase: enforcer of the Circe effect for amino acid substrates and general-base catalyst for the 1,3-prototropic shift.

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Processing of X-ray diffraction data collected in oscillation mode

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Refined crystal structure of porcine class Pi glutathione S-transferase (pGST P1-1) at 2.1 A resolution

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[26] Screening for heavy-atom derivatives and obtaining accurate isomorphous differences.

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[37] Patterson superposition and ab initio phasing

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The CCP4 suite: programs for protein crystallography

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[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

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7 January 2021

Methods used in the structure determination of bovine mitochondrial F1 ATPase

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Improved methods for building protein models in electron density maps and the location of errors in these models

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Torsion angle dynamics: reduced variable conformational sampling enhances crystallographic structure refinement

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Refinement of macromolecular structures by the maximum-likelihood method

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

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7 January 2021

Improved R-factors for diffraction data analysis in macromolecular crystallography

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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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Raster3D: photorealistic molecular graphics

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