WASH complex subunit 1 (Q21992806)

http://www.ebi.ac.uk/interpro/protein/Q8VDD8

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

WASH1, WAHD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

WH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

alpha-tubulin binding

3 references

2 references

gamma-tubulin binding

1 reference

14 February 2019

Functional characterization of Wiskott-Aldrich syndrome protein and scar homolog (WASH), a bi-modular nucleation-promoting factor able to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and gamma-tubulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

low-density lipoprotein particle receptor binding

1 reference

14 February 2019

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

ubiquitin protein ligase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

1 reference

14 February 2019

The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

1 reference

14 February 2019

Functional characterization of Wiskott-Aldrich syndrome protein and scar homolog (WASH), a bi-modular nucleation-promoting factor able to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and gamma-tubulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

early endosome membrane

1 reference

14 February 2019

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

1 reference

14 February 2019

Functional characterization of Wiskott-Aldrich syndrome protein and scar homolog (WASH), a bi-modular nucleation-promoting factor able to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and gamma-tubulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

recycling endosome membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

14 February 2019

The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

14 February 2019

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

intracellular membrane-bounded organelle

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

polar body extrusion after meiotic divisions

biological process

1 reference

14 February 2019

WASH complex regulates Arp2/3 complex for actin-based polar body extrusion in mouse oocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

regulation of protein ubiquitination

1 reference

14 February 2019

WASH inhibits autophagy through suppression of Beclin 1 ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

1 reference

14 February 2019

WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

1 reference

14 February 2019

The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

protein localization to cell surface

1 reference

14 February 2019

WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

1 reference

14 February 2019

WASH complex regulates Arp2/3 complex for actin-based polar body extrusion in mouse oocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

Arp2/3 complex-mediated actin nucleation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

14 February 2019

The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

14 February 2019

Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

negative regulation of phosphatidylinositol 3-kinase activity

IEA

1 reference

14 February 2019

WASH inhibits autophagy through suppression of Beclin 1 ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

regulation of immune response

1 reference

14 February 2019

WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

dendritic cell antigen processing and presentation

1 reference

14 February 2019

Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

negative regulation of autophagy

1 reference

14 February 2019

WASH inhibits autophagy through suppression of Beclin 1 ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

WASH complex regulates Arp2/3 complex for actin-based polar body extrusion in mouse oocytes

meiotic spindle assembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

endosome organization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

regulation of actin filament polymerization

1 reference

14 February 2019

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

low-density lipoprotein particle clearance

1 reference

14 February 2019

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

positive regulation of cholesterol import

1 reference

14 February 2019

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

positive regulation of protein localization to cell surface

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

extracellular matrix disassembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

positive regulation of cell migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

positive regulation of pseudopodium assembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VDD8

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8VDD8

WASH1, WAHD domain

1 reference

stated in

InterPro Release 71.0