Purinergic receptor P2X, ligand-gated ion channel, 7 (Q21990432)

http://www.ebi.ac.uk/interpro/protein/Q9Z1M0

P2X7 purinoceptor

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Z1M0

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

lipopolysaccharide binding

1 reference

14 February 2019

Cutting edge: the nucleotide receptor P2X7 contains multiple protein- and lipid-interaction motifs including a potential binding site for bacterial lipopolysaccharide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

extracellularly ATP-gated cation channel activity

5 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1M0&geneProductId=UniProtKB:Q9Z1M0

16 July 2018

Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1M0&geneProductId=UniProtKB:Q9Z1M0

16 July 2018

Properties of presynaptic P2X7-like receptors at the neuromuscular junction

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1M0&geneProductId=UniProtKB:Q9Z1M0

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1M0&geneProductId=UniProtKB:Q9Z1M0

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1M0&geneProductId=UniProtKB:Q9Z1M0

purinergic nucleotide receptor activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

signaling receptor activity

1 reference

14 February 2019

Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

extracellularly ATP-gated cation channel activity

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Properties of presynaptic P2X7-like receptors at the neuromuscular junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

ATP-gated ion channel activity

IBA

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

integral component of membrane

IBA

cell component

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1M0&geneProductId=UniProtKB:Q9Z1M0

integral component of nuclear inner membrane

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

1 reference

14 February 2019

Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

external side of plasma membrane

1 reference

14 February 2019

P2X7 receptor expression levels determine lethal effects of a purine based danger signal in T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

1 reference

14 February 2019

Synaptic terminals from mice midbrain exhibit functional P2X7 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

Properties of presynaptic P2X7-like receptors at the neuromuscular junction

neuromuscular junction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Properties of presynaptic P2X7-like receptors at the neuromuscular junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

integral component of plasma membrane

3 references

14 February 2019

Cloning and functional characterisation of the mouse P2X7 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

response to electrical stimulus

biological process

1 reference

14 February 2019

Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

cellular response to organic cyclic compound

1 reference

14 February 2019

Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

response to mechanical stimulus

1 reference

14 February 2019

The P2X7 nucleotide receptor mediates skeletal mechanotransduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion

phagolysosome assembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

1 reference

14 February 2019

Altered cytokine production in mice lacking P2X(7) receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

positive regulation of T cell mediated cytotoxicity

1 reference

14 February 2019

The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

ceramide biosynthetic process

1 reference

14 February 2019

ATP-induced apoptosis of thymocytes is mediated by activation of P2 X 7 receptor and involves de novo ceramide synthesis and mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

P2X7 receptor mediated phosphorylation of p38MAP kinase in the hippocampus

protein phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

vesicle budding from membrane

1 reference

14 February 2019

Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

Synaptic terminals from mice midbrain exhibit functional P2X7 receptor

response to calcium ion

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Characterization of a functional P2X(7)-like receptor in cerebellar granule neurons from P2X(7) knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

positive regulation of protein phosphorylation

response to organic substance

3 references

14 February 2019

P2X7 receptors regulate NKT cells in autoimmune hepatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

P2X7 receptor expression levels determine lethal effects of a purine based danger signal in T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

High sensitivity of CD4+CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

positive regulation of MAPK cascade

1 reference

14 February 2019

A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

Cutting edge: purinergic signaling regulates radical-mediated bacterial killing mechanisms in macrophages through a P2X7-independent mechanism

response to bacterium

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

homeostasis of number of cells within a tissue

1 reference

14 February 2019

The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

positive regulation of mitochondrial depolarization

1 reference

14 February 2019

Role of sodium in mitochondrial membrane depolarization induced by P2X7 receptor activation in submandibular glands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

positive regulation of bone mineralization

positive regulation of interleukin-1 beta production

1 reference

14 February 2019

Altered cytokine production in mice lacking P2X(7) receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

response to fluid shear stress

1 reference

14 February 2019

The P2X7 nucleotide receptor mediates skeletal mechanotransduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

collagen metabolic process

1 reference

14 February 2019

The role of purinergic P2X7 receptors in the inflammation and fibrosis of unilateral ureteral obstruction in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

reactive oxygen species metabolic process

1 reference

14 February 2019

Nucleotide receptor signaling in murine macrophages is linked to reactive oxygen species generation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

response to organic cyclic compound

1 reference

14 February 2019

Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

cellular response to dsRNA

1 reference

14 February 2019

TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

positive regulation of protein secretion

1 reference

14 February 2019

Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

skeletal system morphogenesis

1 reference

14 February 2019

P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

protein complex oligomerization

1 reference

14 February 2019

Properties of presynaptic P2X7-like receptors at the neuromuscular junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

1 reference

14 February 2019

High sensitivity of CD4+CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

1 reference

16 July 2018

Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1M0&geneProductId=UniProtKB:Q9Z1M0

1 reference

14 February 2019

Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

1 reference

14 February 2019

P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

release of sequestered calcium ion into cytosol

1 reference

14 February 2019

Synaptic terminals from mice midbrain exhibit functional P2X7 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death

cell volume homeostasis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

extrinsic apoptotic signaling pathway

1 reference

14 February 2019

P2X7 receptor expression levels determine lethal effects of a purine based danger signal in T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

sensory perception of pain

1 reference

14 February 2019

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

positive regulation of interleukin-6 production

1 reference

14 February 2019

Altered cytokine production in mice lacking P2X(7) receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

synaptic vesicle exocytosis

1 reference

14 February 2019

Properties of presynaptic P2X7-like receptors at the neuromuscular junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

cellular response to extracellular stimulus

1 reference

14 February 2019

Synaptic terminals from mice midbrain exhibit functional P2X7 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

phospholipid translocation

1 reference

14 February 2019

Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

response to lipopolysaccharide

3 references

14 February 2019

Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Nucleotide receptor signaling in murine macrophages is linked to reactive oxygen species generation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

positive regulation of gamma-aminobutyric acid secretion

1 reference

14 February 2019

Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

positive regulation of prostaglandin secretion

1 reference

14 February 2019

The P2X7 nucleotide receptor mediates skeletal mechanotransduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

positive regulation of apoptotic process

defense response to Gram-positive bacterium

1 reference

14 February 2019

ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

1 reference

14 February 2019

Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

positive regulation of catalytic activity

1 reference

14 February 2019

The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

2 references

phospholipid transfer to membrane

1 reference

14 February 2019

Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

plasma membrane organization

1 reference

14 February 2019

Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

1 reference

14 February 2019

P2X7 receptors mediate NADH transport across the plasma membranes of astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor

calcium ion transport

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

negative regulation of bone resorption

1 reference

14 February 2019

Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

membrane protein ectodomain proteolysis

1 reference

14 February 2019

P2X7 receptor expression levels determine lethal effects of a purine based danger signal in T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

mitochondrion organization

1 reference

14 February 2019

ATP-induced apoptosis of thymocytes is mediated by activation of P2 X 7 receptor and involves de novo ceramide synthesis and mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

negative regulation of MAPK cascade

1 reference

14 February 2019

Cutting edge: the nucleotide receptor P2X7 contains multiple protein- and lipid-interaction motifs including a potential binding site for bacterial lipopolysaccharide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

positive regulation of lymphocyte apoptotic process

1 reference

14 February 2019

Exacerbation of experimental autoimmune encephalomyelitis in P2X7R-/- mice: evidence for loss of apoptotic activity in lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

cation transmembrane transport

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

3 references

24 April 2018

The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1M0&geneProductId=UniProtKB:Q9Z1M0

24 April 2018

High sensitivity of CD4+CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1M0&geneProductId=UniProtKB:Q9Z1M0

24 April 2018

Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z1M0&geneProductId=UniProtKB:Q9Z1M0

pore complex assembly

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

The P2X7 nucleotide receptor mediates skeletal mechanotransduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

negative regulation of cell volume

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

21 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Synaptic terminals from mice midbrain exhibit functional P2X7 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Role of sodium in mitochondrial membrane depolarization induced by P2X7 receptor activation in submandibular glands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Characterization of a functional P2X(7)-like receptor in cerebellar granule neurons from P2X(7) knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Nucleotide receptor signaling in murine macrophages is linked to reactive oxygen species generation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

High sensitivity of CD4+CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

P2X7 receptor expression levels determine lethal effects of a purine based danger signal in T lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Altered cytokine production in mice lacking P2X(7) receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

ATP-induced apoptosis of thymocytes is mediated by activation of P2 X 7 receptor and involves de novo ceramide synthesis and mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Properties of presynaptic P2X7-like receptors at the neuromuscular junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

programmed cell death

excitatory postsynaptic potential

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

protein catabolic process

1 reference

14 February 2019

Cutting edge: the nucleotide receptor P2X7 contains multiple protein- and lipid-interaction motifs including a potential binding site for bacterial lipopolysaccharide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

3 references

14 February 2019

The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

14 February 2019

High sensitivity of CD4+CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0

ion transmembrane transport

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z1M0