Prostaglandin-endoperoxide synthase 2 (Q21988894)

prostaglandin-endoperoxide synthase activity

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

IDA

oxidoreductase activity

1 reference

8 April 2019

protein homodimerization activity

1 reference

8 April 2019

A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

1 reference

8 April 2019

S-nitrosylation/activation of COX-2 mediates NMDA neurotoxicity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

3 references

8 April 2019

Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

endoplasmic reticulum

intracellular membrane-bounded organelle

ISO

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

endoplasmic reticulum membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

response to organic substance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

cellular response to mechanical stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

response to manganese ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

cellular response to hypoxia

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

prostaglandin metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

response to oxidative stress

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

response to lithium ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

response to tumor necrosis factor

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

fatty acid biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

response to organonitrogen compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

response to fatty acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

response to vitamin D

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

cellular response to UV

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

cellular response to fluid shear stress

1 reference

8 April 2019

Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

brown fat cell differentiation

IDA

1 reference

8 April 2019

Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

response to radiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

cellular response to ATP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

response to estradiol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

response to organic cyclic compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

cellular oxidant detoxification

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

response to glucocorticoid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

cyclooxygenase pathway

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

fatty acid metabolic process

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

keratinocyte differentiation

1 reference

8 April 2019

Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

regulation of cell population proliferation

NAS

5 references

8 April 2019

Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

positive regulation of brown fat cell differentiation

IGI

1 reference

8 April 2019

Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

cellular response to heat

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

positive regulation of prostaglandin biosynthetic process

1 reference

8 April 2019

Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

positive regulation of peptidyl-serine phosphorylation

1 reference

8 April 2019

Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

negative regulation of apoptotic process

1 reference

8 April 2019

Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

cellular response to non-ionic osmotic stress

1 reference

8 April 2019

Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

1 reference

8 April 2019

Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

cellular response to lead ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

response to angiotensin

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

prostaglandin biosynthetic process

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

8 April 2019

A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

3 references

positive regulation of fever generation

3 references

regulation of neuroinflammatory response

1 reference

8 April 2019

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05769

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q05769

Identifiers

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20 March 2022

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25 May 2022

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9 August 2016

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