Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (Q21988832)

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mouse protein (annotated by UniProtKB/Swiss-Prot O88491)

H4-K20-HMTase
Nuclear receptor-binding SET domain-containing protein 1
NR-binding SET domain-containing protein
H3-K36-HMTase

Language	Label	Description	Also known as
English	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific	mouse protein (annotated by UniProtKB/Swiss-Prot O88491)	H4-K20-HMTase Nuclear receptor-binding SET domain-containing protein 1 NR-binding SET domain-containing protein H3-K36-HMTase

Statements

0 references

Zinc finger, FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88491

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88491

Zinc finger, PHD-finger, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, PHD-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Post-SET domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, RING-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

SET domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PWWP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

AWS domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, PHD-type, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

molecular function

metal ion binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

transcription corepressor activity

determination method

1 reference

14 February 2019

Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

transferase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

histone methyltransferase activity (H4-K20 specific)

determination method

1 reference

14 February 2019

NSD1 is essential for early post-implantation development and has a catalytically active SET domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

thyroid hormone receptor binding

determination method

1 reference

14 February 2019

Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

retinoid X receptor binding

determination method

1 reference

14 February 2019

Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

histone-lysine N-methyltransferase activity

determination method

2 references

chromatin binding

determination method

1 reference

14 February 2019

Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

androgen receptor binding

determination method

2 references

estrogen receptor binding

determination method

1 reference

14 February 2019

Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

retinoic acid receptor binding

determination method

1 reference

14 February 2019

Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

methyltransferase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

histone methyltransferase activity

determination method

1 reference

14 February 2019

NSD1 is essential for early post-implantation development and has a catalytically active SET domain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

transcription coregulator activity

determination method

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

14 February 2019

Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

zinc ion binding

determination method

2 references

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

14 February 2019

Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

histone methyltransferase activity (H3-K36 specific)

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

14 February 2019

NSD1 is essential for early post-implantation development and has a catalytically active SET domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

histone methyltransferase complex

determination method

1 reference

14 February 2019

NSD1 is essential for early post-implantation development and has a catalytically active SET domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

determination method

4 references

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88491&geneProductId=UniProtKB:O88491

determination method

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88491&geneProductId=UniProtKB:O88491

determination method

10 September 2018

Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88491&geneProductId=UniProtKB:O88491

determination method

10 September 2018

Nizp1, a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motif

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88491&geneProductId=UniProtKB:O88491

determination method

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

determination method

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

14 February 2019

Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

14 February 2019

Nizp1, a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motif

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

biological process

regulation of histone H3-K36 methylation

determination method

1 reference

14 February 2019

Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

histone methylation

determination method

1 reference

14 February 2019

NSD1 is essential for early post-implantation development and has a catalytically active SET domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

gastrulation with mouth forming second

determination method

1 reference

14 February 2019

NSD1 is essential for early post-implantation development and has a catalytically active SET domain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

transcription, DNA-templated

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88491&geneProductId=UniProtKB:O88491

determination method

multicellular organism development

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

14 February 2019

Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

regulation of peptidyl-serine phosphorylation

determination method

1 reference

14 February 2019

Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

regulation of RNA polymerase II regulatory region sequence-specific DNA binding

determination method

1 reference

14 February 2019

Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

histone H3-K36 methylation

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

histone lysine methylation

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

histone H4-K20 methylation

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

chromatin organization

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O88491

determination method

regulation of transcription, DNA-templated

determination method

1 reference

10 September 2018

Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O88491&geneProductId=UniProtKB:O88491

determination method

regulation of transcription, DNA-templated

determination method

Zinc finger, PHD-type, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88491

Post-SET domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88491

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88491

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88491

Zinc finger, RING-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88491

Zinc finger, PHD-finger

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88491

Zinc finger, PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88491

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O88491

Identifiers

UniProt protein ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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