Sterol regulatory element binding transcription factor 1 (Q21988573)

protein dimerization activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

1 reference

14 February 2019

transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding

1 reference

11 October 2018

Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTN3&geneProductId=UniProtKB:Q9WTN3

DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

3 references

14 February 2019

14 February 2019

Salt-inducible kinase regulates hepatic lipogenesis by controlling SREBP-1c phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Lipid deprivation increases surfactant phosphatidylcholine synthesis via a sterol-sensitive regulatory element within the CTP:phosphocholine cytidylyltransferase promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

protein binding

7 references

14 February 2019

Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

PIASy-mediated sumoylation of SREBP1c regulates hepatic lipid metabolism upon fasting signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

DNA-binding transcription factor activity

Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c

3 references

14 February 2019

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

sterol response element binding

Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c

3 references

14 February 2019

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

RNA polymerase II cis-regulatory region sequence-specific DNA binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

DNA-binding transcription activator activity, RNA polymerase II-specific

4 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTN3&geneProductId=UniProtKB:Q9WTN3

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTN3&geneProductId=UniProtKB:Q9WTN3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

chromatin binding

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

sequence-specific DNA binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

enzyme activator activity

1 reference

14 February 2019

Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

14 February 2019

Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

cell component

cytoplasm

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

1 reference

14 February 2019

integral component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

1 reference

14 February 2019

ER to Golgi transport vesicle membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

1 reference

14 February 2019

Golgi apparatus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

1 reference

14 February 2019

endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

1 reference

14 February 2019

cytoplasmic vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

1 reference

14 February 2019

nucleus

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

positive regulation of fatty acid biosynthetic process

biological process

1 reference

14 February 2019

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

response to glucagon

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

steroid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

1 reference

14 February 2019

positive regulation of histone deacetylation

1 reference

14 February 2019

Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

regulation of fatty acid metabolic process

1 reference

14 February 2019

Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTN3&geneProductId=UniProtKB:Q9WTN3

1 reference

16 July 2018

lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

1 reference

14 February 2019

insulin receptor signaling pathway

1 reference

14 February 2019

Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

lung development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

mRNA transcription by RNA polymerase II

1 reference

14 February 2019

Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

positive regulation of triglyceride biosynthetic process

cellular response to insulin stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

response to lipid

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

regulation of heart rate by chemical signal

1 reference

14 February 2019

Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

response to cAMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

response to progesterone

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

lipid biosynthetic process

1 reference

16 July 2018

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTN3&geneProductId=UniProtKB:Q9WTN3

response to organic cyclic compound

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

positive regulation of cholesterol biosynthetic process

2 references

14 February 2019

Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

response to peptide hormone

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

cellular response to fatty acid

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

negative regulation of transcription by RNA polymerase II

Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

IGI

14 February 2019

Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

response to fatty acid

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

fat cell differentiation

1 reference

14 February 2019

Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

ageing

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

response to food

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

3 references

14 February 2019

14 February 2019

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

regulation of insulin secretion

1 reference

14 February 2019

SREBP1 is required for the induction by glucose of pancreatic beta-cell genes involved in glucose sensing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

response to glucose

1 reference

14 February 2019

SREBP1 is required for the induction by glucose of pancreatic beta-cell genes involved in glucose sensing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

response to retinoic acid

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

negative regulation of insulin secretion

1 reference

14 February 2019

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

intracellular receptor signaling pathway

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

positive regulation of transcription by RNA polymerase II

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

circadian rhythm

IEP

1 reference

14 February 2019

The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

cholesterol metabolic process

IEP

cellular response to starvation

ISO

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

positive regulation of transcription, DNA-templated

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

14 February 2019

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

lipid biosynthetic process

positive regulation of catalytic activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

positive regulation of pri-miRNA transcription by RNA polymerase II

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3

regulation of transcription, DNA-templated

ISO

2 references

10 September 2018

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTN3&geneProductId=UniProtKB:Q9WTN3

10 September 2018

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WTN3&geneProductId=UniProtKB:Q9WTN3

macromolecule metabolic process

1 reference

14 February 2019

Adropin Deficiency Is Associated With Increased Adiposity and Insulin Resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WTN3