SRY (sex determining region Y)-box 2 (Q21988352)

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mammalian protein found in Mus musculus
  • transcription factor SOX-2
  • Sox2
  • SRY-box containing gene 2
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Language Label Description Also known as
English
SRY (sex determining region Y)-box 2
mammalian protein found in Mus musculus
  • transcription factor SOX-2
  • Sox2
  • SRY-box containing gene 2

Statements

molecular function
DNA binding
determination method
IDA
IGI
IEA
ISO
7 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
ISO
retrieved
14 February 2019
stated in
Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IGI
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P48432
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IEA
retrieved
14 February 2019
stated in
Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
SOX7 and GATA-4 are competitive activators of Fgf-3 transcription
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
sequence-specific DNA binding
determination method
IDA
ISO
6 references
retrieved
14 February 2019
stated in
Pluripotency factors regulate definitive endoderm specification through eomesodermin
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
ISO
retrieved
14 February 2019
stated in
Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells
GOA
curator
UniProt
UniProt protein ID
P48432
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Role of the transcription factor Sox-2 in the expression of the FGF-4 gene in embryonal carcinoma cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Involvement of SOX proteins in lens-specific activation of crystallin genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
DNA-binding transcription factor activity
determination method
IDA
ISO
7 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
ISO
retrieved
14 February 2019
stated in
Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells
GOA
curator
UniProt
UniProt protein ID
P48432
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Inhibition of DNA binding of Sox2 by the SUMO conjugation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Involvement of SOX proteins in lens-specific activation of crystallin genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Role of the transcription factor Sox-2 in the expression of the FGF-4 gene in embryonal carcinoma cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
protein binding
determination method
IPI
14 references
retrieved
14 February 2019
stated in
Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells
GOA
curator
UniProt
UniProt protein ID
P48432
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IPI
retrieved
14 February 2019
stated in
Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells.
GOA
curator
UniProt
UniProt protein ID
P48432
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IPI
retrieved
14 February 2019
stated in
Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IPI
retrieved
14 February 2019
stated in
A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IPI
retrieved
14 February 2019
stated in
Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IPI
retrieved
14 February 2019
stated in
Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IPI
retrieved
14 February 2019
stated in
Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IPI
retrieved
14 February 2019
stated in
Cdk1 interplays with Oct4 to repress differentiation of embryonic stem cells into trophectoderm
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IPI
retrieved
14 February 2019
stated in
A positive regulatory role for the mSin3A-HDAC complex in pluripotency through Nanog and Sox2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IPI
retrieved
14 February 2019
stated in
A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IPI
retrieved
14 February 2019
stated in
An Oct4-centered protein interaction network in embryonic stem cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IPI
retrieved
14 February 2019
stated in
The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IPI
retrieved
14 February 2019
stated in
Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IPI
retrieved
14 February 2019
stated in
Sall1 regulates embryonic stem cell differentiation in association with nanog
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IPI
cell component
nucleus
determination method
IC
IDA
IEA
ISO
26 references
retrieved
24 April 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
ISO
retrieved
24 April 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P48432
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IEA
retrieved
24 April 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IEA
retrieved
24 April 2018
stated in
Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis
GOA
curator
UniProt
UniProt protein ID
P48432
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Role of Sox2 in the development of the mouse neocortex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Sox9 plays multiple roles in the lung epithelium during branching morphogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Pwp1 is required for the differentiation potential of mouse embryonic stem cells through regulating Stat3 signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Multipotent cell lineages in early mouse development depend on SOX2 function
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IC
nucleus
determination method
IBA
IC
IDA
IEA
ISO
27 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P48432
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IEA
retrieved
14 February 2019
stated in
Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis
GOA
curator
UniProt
UniProt protein ID
P48432
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Sox9 plays multiple roles in the lung epithelium during branching morphogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Pwp1 is required for the differentiation potential of mouse embryonic stem cells through regulating Stat3 signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Multipotent cell lineages in early mouse development depend on SOX2 function
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Role of Sox2 in the development of the mouse neocortex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IC
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IBA
biological process
positive regulation of transcription by RNA polymerase II
determination method
IDA
IGI
IMP
ISO
11 references
retrieved
24 April 2018
stated in
Pluripotency factors regulate definitive endoderm specification through eomesodermin
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
ISO
retrieved
24 April 2018
stated in
Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IMP
retrieved
24 April 2018
stated in
A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IGI
retrieved
24 April 2018
stated in
Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IGI
retrieved
24 April 2018
stated in
Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IGI
retrieved
24 April 2018
stated in
Sox2 and Pou2f1 interact to control lens and olfactory placode development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IGI
retrieved
24 April 2018
stated in
Inhibition of DNA binding of Sox2 by the SUMO conjugation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IGI
retrieved
24 April 2018
stated in
Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Involvement of SOX proteins in lens-specific activation of crystallin genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
24 April 2018
stated in
Inhibition of DNA binding of Sox2 by the SUMO conjugation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P48432&geneProductId=UniProtKB:P48432
determination method
IDA
positive regulation of transcription by RNA polymerase II
determination method
IBA
IDA
IGI
IMP
ISO
12 references
retrieved
14 February 2019
stated in
Pluripotency factors regulate definitive endoderm specification through eomesodermin
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
ISO
retrieved
14 February 2019
stated in
Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IMP
retrieved
14 February 2019
stated in
Inhibition of DNA binding of Sox2 by the SUMO conjugation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IGI
retrieved
14 February 2019
stated in
Sox2 and Pou2f1 interact to control lens and olfactory placode development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IGI
retrieved
14 February 2019
stated in
A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IGI
retrieved
14 February 2019
stated in
Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IGI
retrieved
14 February 2019
stated in
Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IGI
retrieved
14 February 2019
stated in
Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Inhibition of DNA binding of Sox2 by the SUMO conjugation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Involvement of SOX proteins in lens-specific activation of crystallin genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48432
determination method
IBA

Identifiers

 
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