Prostaglandin E receptor 4 (subtype EP4) (Q21987843)

http://www.ebi.ac.uk/interpro/protein/P32240

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

signal transducer activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32240&geneProductId=UniProtKB:P32240

prostaglandin receptor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

prostaglandin E receptor activity

5 references

24 April 2018

Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32240&geneProductId=UniProtKB:P32240

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32240&geneProductId=UniProtKB:P32240

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32240&geneProductId=UniProtKB:P32240

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32240&geneProductId=UniProtKB:P32240

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32240&geneProductId=UniProtKB:P32240

prostaglandin E receptor activity

6 references

9 May 2019

Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

2 references

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

neuron projection terminus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

response to mechanical stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

cellular response to mechanical stimulus

1 reference

9 May 2019

p38 MAP kinase mediates mechanically induced COX-2 and PG EP4 receptor expression in podocytes: implications for the actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of inflammatory response

IEP

1 reference

9 May 2019

Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

response to lipopolysaccharide

IDA

1 reference

9 May 2019

Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

adenylate cyclase-activating G protein-coupled receptor signaling pathway

IMP

1 reference

24 April 2018

Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32240&geneProductId=UniProtKB:P32240

regulation of ossification

TAS

1 reference

9 May 2019

Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

regulation of stress fiber assembly

IMP

1 reference

9 May 2019

p38 MAP kinase mediates mechanically induced COX-2 and PG EP4 receptor expression in podocytes: implications for the actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

T-helper cell differentiation

1 reference

9 May 2019

Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

negative regulation of integrin activation

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

negative regulation of eosinophil extravasation

negative regulation of inflammatory response

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

14 February 2019

Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

14 February 2019

Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

cellular response to prostaglandin E stimulus

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of protein phosphorylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

negative regulation of peptide secretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of cell population proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of gene expression

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

negative regulation of hydrogen peroxide metabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

regulation of circadian sleep/wake cycle, wakefulness

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of smooth muscle cell migration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

negative regulation of tumor necrosis factor production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of interleukin-8 production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of urine volume

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of renal sodium excretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

negative regulation of circadian sleep/wake cycle, REM sleep

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of tyrosine phosphorylation of STAT protein

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of cAMP-mediated signaling

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of osteoblast differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of ossification

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of bone resorption

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of cell adhesion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of circadian sleep/wake cycle, non-REM sleep

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of protein secretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

negative regulation of nitric-oxide synthase biosynthetic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of mucus secretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of wound healing

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

ductus arteriosus closure

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of hyaluronan biosynthetic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

negative regulation of ductus arteriosus closure

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

negative regulation of small intestine smooth muscle contraction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of calcitonin secretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of chemokinesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of substance P secretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of matrix metallopeptidase secretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

negative regulation of endothelin production

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of substance P secretion, neurotransmission

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of ovarian follicle development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of antral ovarian follicle growth

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of neutrophil extravasation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

inflammatory response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

positive regulation of cytosolic calcium ion concentration

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

negative regulation of inflammatory response

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

9 May 2019

Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

9 May 2019

Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32240

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

1882

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

1883

language of work or name

English

retrieved

17 August 2016

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

stated in

InterPro Release 71.0