Prostaglandin E2 receptor EP3 subtype (Q21987842)

http://www.ebi.ac.uk/interpro/protein/P30557

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

9 August 2016

1 reference

9 August 2016

prostaglandin receptor activity

English

molecular function

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

1 reference

9 May 2019

The C-terminus of the prostaglandin-E-receptor EP3 subtype is essential for activation of GTP-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

signal transducer activity

IPI

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30557&geneProductId=UniProtKB:P30557

prostaglandin E receptor activity

IEA

7 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30557&geneProductId=UniProtKB:P30557

24 April 2018

Expression and site-directed mutagenesis of mouse prostaglandin E2 receptor EP3 subtype in insect cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30557&geneProductId=UniProtKB:P30557

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30557&geneProductId=UniProtKB:P30557

24 April 2018

Mouse prostaglandin E receptor EP3 subtype mediates calcium signals via Gi in cDNA-transfected Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30557&geneProductId=UniProtKB:P30557

24 April 2018

Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30557&geneProductId=UniProtKB:P30557

24 April 2018

Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30557&geneProductId=UniProtKB:P30557

24 April 2018

The C-terminus of the prostaglandin-E-receptor EP3 subtype is essential for activation of GTP-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30557&geneProductId=UniProtKB:P30557

prostaglandin E receptor activity

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

9 May 2019

Expression and site-directed mutagenesis of mouse prostaglandin E2 receptor EP3 subtype in insect cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

9 May 2019

The C-terminus of the prostaglandin-E-receptor EP3 subtype is essential for activation of GTP-binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

9 May 2019

Mouse prostaglandin E receptor EP3 subtype mediates calcium signals via Gi in cDNA-transfected Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

9 May 2019

Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

14 February 2019

Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

14 February 2019

Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

brush border membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

proximal neuron projection

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

9 May 2019

Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

9 May 2019

Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

Impaired duodenal bicarbonate secretion and mucosal integrity in mice lacking prostaglandin E-receptor subtype EP(3)

biological process

bicarbonate transport

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

phospholipase C-activating G protein-coupled receptor signaling pathway

IMP

1 reference

24 April 2018

Mouse prostaglandin E receptor EP3 subtype mediates calcium signals via Gi in cDNA-transfected Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30557&geneProductId=UniProtKB:P30557

positive regulation of fever generation

1 reference

9 May 2019

Central control of fever and female body temperature by RANKL/RANK

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

response to lipopolysaccharide

IMP

1 reference

9 May 2019

Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

positive regulation of urine volume

IMP

1 reference

9 May 2019

Urinary concentrating function in mice lacking EP3 receptors for prostaglandin E2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

IEA

2 references

9 May 2019

Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

9 May 2019

Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

positive regulation of protein phosphorylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

desensitization of G protein-coupled receptor signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

positive regulation of gene expression

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

negative regulation of norepinephrine secretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

regulation of circadian sleep/wake cycle, wakefulness

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

regulation of norepinephrine secretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

urinary bladder smooth muscle contraction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

receptor internalization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

positive regulation of cAMP-mediated signaling

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

positive regulation of vasoconstriction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

positive regulation of circadian sleep/wake cycle, non-REM sleep

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

negative regulation of insulin secretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

negative regulation of platelet aggregation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

negative regulation of potassium ion transmembrane transport

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

negative regulation of calcium ion transmembrane transport

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

positive regulation of blood circulation

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30557&geneProductId=UniProtKB:P30557

negative regulation of gastrin-induced gastric acid secretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

positive regulation of smooth muscle contraction involved in micturition

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

cellular response to forskolin

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

positive regulation of inhibitory G protein-coupled receptor phosphorylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

negative regulation of circadian sleep/wake cycle, wakefulness

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

positive regulation of myofibroblast contraction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

positive regulation of colon smooth muscle contraction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

positive regulation of gastric mucosal blood circulation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

prostaglandin receptor internalization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

positive regulation of neutrophil extravasation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

negative regulation of forebrain neuron differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

inflammatory response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

adenylate cyclase-activating G protein-coupled receptor signaling pathway

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

9 May 2019

Mouse prostaglandin E receptor EP3 subtype mediates calcium signals via Gi in cDNA-transfected Chinese hamster ovary cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30557

physically interacts with

1 reference

1881

17 August 2016

1 reference

1882

17 August 2016

1 reference

1883

17 August 2016

1 reference

1884

17 August 2016

1 reference

1919

GPCR, rhodopsin-like, 7TM

English

retrieved

17 August 2016

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30557

Identifiers

1 reference

9 August 2016