Notch 1 (Q21986193)

Neurogenic locus Notch 1

1 reference

Growth factor receptor cysteine-rich domain superfamily

1 reference

Ankyrin repeat-containing domain superfamily

1 reference

membrane proteins

1 reference

inferred from GOA cell component → membrane

Notch, NODP domain, protein family

1 reference

Notch proteins

1 reference

Notch, NOD domain, protein family

1 reference

Domain of unknown function DUF3454, notch, protein family

1 reference

Ankyrin repeat-containing domain, protein family

1 reference

EGF-like calcium-binding domain, protein family

1 reference

EGF-like domain, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

EGF-like calcium-binding, conserved site, protein family

1 reference

Ankyrin repeat, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 May 2019

1 reference

9 May 2019

Notch4 reveals a novel mechanism regulating Notch signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

enzyme inhibitor activity

IPI

1 reference

9 May 2019

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

18 references

9 May 2019

Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Consequences of MEGF10 deficiency on myoblast function and Notch1 interactions.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Delta-like 1-Lysine613 regulates notch signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Pten coordinates retinal neurogenesis by regulating Notch signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Notch1 regulates the fate of cardiac progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

A protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 interacts with Notch1 and Notch3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

A protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 interacts with Notch1 and Notch3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

sequence-specific DNA binding

IPI

1 reference

9 May 2019

Notch directly regulates Gata3 expression during T helper 2 cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

protein heterodimerization activity

1 reference

9 May 2019

Notch4 reveals a novel mechanism regulating Notch signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

Notch directly regulates Gata3 expression during T helper 2 cell differentiation

chromatin DNA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

signaling receptor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

9 May 2019

ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

9 May 2019

Notch signaling is essential for ventricular chamber development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

DNER acts as a neuron-specific Notch ligand during Bergmann glial development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

14 February 2019

Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates

apical plasma membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

Notch4 reveals a novel mechanism regulating Notch signal transduction

endoplasmic reticulum

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

endoplasmic reticulum membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

integral component of plasma membrane

TAS

1 reference

9 May 2019

Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

Notch4 reveals a novel mechanism regulating Notch signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

12 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Canonical notch signaling functions as a commitment switch in the epidermal lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Notch signaling is essential for ventricular chamber development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Monitoring Notch1 activity in development: evidence for a feedback regulatory loop

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

Notch4 reveals a novel mechanism regulating Notch signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

Canonical notch signaling functions as a commitment switch in the epidermal lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

Notch-Tnf signalling is required for development and homeostasis of arterial valves.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

MAML1-RBP-Jkappa- ICN1 complex

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

8 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Canonical notch signaling functions as a commitment switch in the epidermal lineage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Notch4 reveals a novel mechanism regulating Notch signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Notch-Tnf signalling is required for development and homeostasis of arterial valves.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

cardiac vascular smooth muscle cell development

IBA

biological process

1 reference

9 May 2019

Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of aorta morphogenesis

1 reference

9 May 2019

Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

Notch signaling controls multiple steps of pancreatic differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

regulation of somitogenesis

1 reference

9 May 2019

Notch1 is required for the coordinate segmentation of somites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

cell differentiation in spinal cord

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

regulation of extracellular matrix assembly

1 reference

9 May 2019

Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

distal tubule development

1 reference

9 May 2019

Segmental expression of Notch and Hairy genes in nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of glial cell proliferation

IEP

1 reference

9 May 2019

Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

epithelial to mesenchymal transition involved in endocardial cushion formation

1 reference

9 May 2019

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

regulation of transcription by RNA polymerase II

aortic valve morphogenesis

oligodendrocyte differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of osteoblast differentiation

1 reference

9 May 2019

Notch1 represses osteogenic pathways in aortic valve cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of ossification

1 reference

9 May 2019

Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

Notch signaling regulates left-right asymmetry determination by inducing Nodal expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of photoreceptor cell differentiation

1 reference

9 May 2019

Notch 1 inhibits photoreceptor production in the developing mammalian retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

arterial endothelial cell differentiation

1 reference

9 May 2019

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation

1 reference

9 May 2019

A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

humoral immune response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

Direct regulation of intestinal fate by Notch

foregut morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of oligodendrocyte differentiation

1 reference

9 May 2019

Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

regulation of developmental process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of cardiac muscle cell proliferation

1 reference

9 May 2019

Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

mesenchymal cell development

1 reference

9 May 2019

Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

animal organ regeneration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of pro-B cell differentiation

1 reference

9 May 2019

Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

vasculogenesis involved in coronary vascular morphogenesis

1 reference

9 May 2019

Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

regulation of neurogenesis

1 reference

9 May 2019

Conservation of the Notch signalling pathway in mammalian neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of Notch signaling pathway

1 reference

9 May 2019

Notch4 reveals a novel mechanism regulating Notch signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of cell population proliferation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

collecting duct development

1 reference

9 May 2019

Segmental expression of Notch and Hairy genes in nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

heart trabecula morphogenesis

ISS

1 reference

9 May 2019

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

atrioventricular node development

1 reference

9 May 2019

Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

Direct regulation of intestinal fate by Notch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

regulation of transcription, DNA-templated

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

venous blood vessel morphogenesis

1 reference

9 May 2019

Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

Functional diversity of notch family genes in fetal lung development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of inner ear auditory receptor cell differentiation

1 reference

9 May 2019

Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

cardiac septum morphogenesis

1 reference

9 May 2019

Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of cell differentiation

1 reference

9 May 2019

Functional diversity of notch family genes in fetal lung development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

coronary artery morphogenesis

1 reference

9 May 2019

Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

response to muramyl dipeptide

1 reference

9 May 2019

Intracellular pathogen sensor NOD2 programs macrophages to trigger Notch1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

cardiac left ventricle morphogenesis

1 reference

9 May 2019

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

in utero embryonic development

1 reference

9 May 2019

Notch1 is required for the coordinate segmentation of somites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of cell death

1 reference

9 May 2019

Notch1 is required for the coordinate segmentation of somites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

endocardial cell differentiation

1 reference

9 May 2019

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

transcription, DNA-templated

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01705&geneProductId=UniProtKB:Q01705

positive regulation of transcription, DNA-templated

3 references

9 May 2019

ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

RBP-L, a transcription factor related to RBP-Jkappa

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

prostate gland epithelium morphogenesis

1 reference

9 May 2019

Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

embryonic limb morphogenesis

1 reference

9 May 2019

Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

growth involved in heart morphogenesis

1 reference

9 May 2019

Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

Notch1 is required for the coordinate segmentation of somites

neural tube development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

pericardium morphogenesis

3 references

9 May 2019

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis

epidermis development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of viral transcription

1 reference

5 June 2018

A protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 interacts with Notch1 and Notch3

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01705&geneProductId=UniProtKB:Q01705

cardiac atrium morphogenesis

1 reference

9 May 2019

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

osteoblast fate commitment

1 reference

9 May 2019

Mutations in NOTCH1 cause aortic valve disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

cardiac right atrium morphogenesis

NAS

1 reference

9 May 2019

Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

cell migration involved in endocardial cushion formation

1 reference

9 May 2019

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

4 references

9 May 2019

Notch1 control of oligodendrocyte differentiation in the spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Notch signaling controls multiple steps of pancreatic differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

venous endothelial cell differentiation

1 reference

9 May 2019

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

regulation of inner ear auditory receptor cell differentiation

1 reference

9 May 2019

Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of catalytic activity

1 reference

9 May 2019

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

inflammatory response to antigenic stimulus

1 reference

9 May 2019

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of astrocyte differentiation

1 reference

9 May 2019

Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of epithelial cell proliferation

1 reference

9 May 2019

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

cardiac right ventricle formation

1 reference

9 May 2019

A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

endocardial cushion development

1 reference

9 May 2019

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism

cell fate specification

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of neurogenesis

1 reference

9 May 2019

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

glomerular mesangial cell development

1 reference

9 May 2019

Segmental expression of Notch and Hairy genes in nephrogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

Essential role of endothelial Notch1 in angiogenesis

IEP

sprouting angiogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

glial cell differentiation

1 reference

9 May 2019

DNER acts as a neuron-specific Notch ligand during Bergmann glial development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of transcription by RNA polymerase II

4 references

9 May 2019

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Mutations in NOTCH1 cause aortic valve disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

cardiac muscle cell proliferation

1 reference

9 May 2019

Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development

1 reference

9 May 2019

Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of epithelial to mesenchymal transition

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

ventricular trabecula myocardium morphogenesis

1 reference

9 May 2019

Notch signaling is essential for ventricular chamber development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

neuronal stem cell population maintenance

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of cell migration involved in sprouting angiogenesis

3 references

response to lipopolysaccharide

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

compartment pattern specification

1 reference

9 May 2019

Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

Conservation of the Notch signalling pathway in mammalian neurogenesis

neuron differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

epithelial to mesenchymal transition

1 reference

9 May 2019

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of BMP signaling pathway

1 reference

9 May 2019

ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

skeletal muscle cell differentiation

1 reference

9 May 2019

Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of viral genome replication

1 reference

9 May 2019

A protein (ORF2) encoded by the latency-related gene of bovine herpesvirus 1 interacts with Notch1 and Notch3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

regulation of epithelial cell proliferation involved in prostate gland development

1 reference

9 May 2019

Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

cardiac ventricle morphogenesis

1 reference

9 May 2019

Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

branching morphogenesis of an epithelial tube

1 reference

9 May 2019

Functional diversity of notch family genes in fetal lung development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of receptor signaling pathway via JAK-STAT

1 reference

9 May 2019

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

Notch signaling involved in heart development

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

coronary vein morphogenesis

1 reference

9 May 2019

Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

regulation of cell adhesion involved in heart morphogenesis

1 reference

9 May 2019

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

apoptotic process involved in embryonic digit morphogenesis

IC

1 reference

9 May 2019

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

regulation of cell migration

1 reference

9 May 2019

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of ephrin receptor signaling pathway

1 reference

9 May 2019

Notch signaling is essential for ventricular chamber development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of cell migration

1 reference

9 May 2019

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

cardiac muscle tissue morphogenesis

1 reference

9 May 2019

Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of endothelial cell chemotaxis

3 references

keratinocyte differentiation

1 reference

9 May 2019

High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of BMP signaling pathway

1 reference

9 May 2019

Notch1 represses osteogenic pathways in aortic valve cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

endocardial cushion morphogenesis

1 reference

24 April 2018

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01705&geneProductId=UniProtKB:Q01705

Notch signaling is essential for ventricular chamber development

endocardium development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

auditory receptor cell fate commitment

1 reference

9 May 2019

Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

3 references

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of calcium ion-dependent exocytosis

1 reference

9 May 2019

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

response to corticosteroid

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of cell population proliferation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of myotube differentiation

1 reference

9 May 2019

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

1 reference

9 May 2019

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

cardiac chamber formation

1 reference

9 May 2019

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

cellular response to vascular endothelial growth factor stimulus

3 references

neuron fate commitment

1 reference

9 May 2019

Notch signaling coordinates the patterning of striatal compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

regulation of epithelial cell proliferation

1 reference

9 May 2019

Direct regulation of intestinal fate by Notch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

regulation of Notch signaling pathway

1 reference

9 May 2019

Notch4 reveals a novel mechanism regulating Notch signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

left/right axis specification

1 reference

9 May 2019

Notch signaling regulates left-right asymmetry determination by inducing Nodal expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of transcription by RNA polymerase II

16 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Notch signaling is essential for ventricular chamber development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Mutations in NOTCH1 cause aortic valve disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Notch directly regulates Gata3 expression during T helper 2 cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Fjx1: a notch-inducible secreted ligand with specific binding sites in developing mouse embryos and adult brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

cardiac epithelial to mesenchymal transition

1 reference

9 May 2019

Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

embryonic hindlimb morphogenesis

1 reference

9 May 2019

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

transcription by RNA polymerase II

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01705&geneProductId=UniProtKB:Q01705

Notch signaling pathway

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

The EGF-like proteins DLK1 and DLK2 function as inhibitory non-canonical ligands of NOTCH1 receptor that modulate each other's activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of transcription of Notch receptor target

IC

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

regulation of cell population proliferation

3 references

negative regulation of neuron differentiation

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Notch signaling coordinates the patterning of striatal compartments

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

outflow tract morphogenesis

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01705&geneProductId=UniProtKB:Q01705

aortic valve morphogenesis

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

Notch-Tnf signalling is required for development and homeostasis of arterial valves.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

coronary sinus valve morphogenesis

1 reference

9 May 2019

Notch-Tnf signalling is required for development and homeostasis of arterial valves.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

pulmonary valve morphogenesis

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

Notch-Tnf signalling is required for development and homeostasis of arterial valves.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of extracellular matrix constituent secretion

1 reference

9 May 2019

Notch-Tnf signalling is required for development and homeostasis of arterial valves.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of cardiac muscle hypertrophy

1 reference

9 May 2019

Notch-Tnf signalling is required for development and homeostasis of arterial valves.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of gene expression

3 references

5 June 2018

Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01705&geneProductId=UniProtKB:Q01705

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01705&geneProductId=UniProtKB:Q01705

5 June 2018

Inhibitory role of Notch1 in calcific aortic valve disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01705&geneProductId=UniProtKB:Q01705

homeostasis of number of cells within a tissue

1 reference

9 May 2019

Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

ventricular septum morphogenesis

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

Notch-Tnf signalling is required for development and homeostasis of arterial valves.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of apoptotic process involved in morphogenesis

1 reference

9 May 2019

Notch-Tnf signalling is required for development and homeostasis of arterial valves.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of gene expression

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Inhibitory role of Notch1 in calcific aortic valve disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of cold-induced thermogenesis

1 reference

9 May 2019

Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

outflow tract morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

aortic valve morphogenesis

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Notch-Tnf signalling is required for development and homeostasis of arterial valves.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

pulmonary valve morphogenesis

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Notch-Tnf signalling is required for development and homeostasis of arterial valves.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

mitral valve formation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

Notch signaling pathway

8 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

The EGF-like proteins DLK1 and DLK2 function as inhibitory non-canonical ligands of NOTCH1 receptor that modulate each other's activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of cell population proliferation

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of gene expression

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of cell-substrate adhesion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of myoblast differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of growth rate

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of Ras protein signal transduction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

ventricular septum morphogenesis

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Notch-Tnf signalling is required for development and homeostasis of arterial valves.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

Notch signaling involved in heart development

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

9 May 2019

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

positive regulation of ERK1 and ERK2 cascade

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

cellular response to follicle-stimulating hormone stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of stem cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

negative regulation of anoikis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01705

ankyrin repeat-containing domain

has part(s)

1 reference

Notch domain

1 reference

EGF-like calcium-binding, conserved site

1 reference

EGF-like calcium-binding domain

1 reference

EGF-like, conserved site

1 reference

Notch, NOD domain

1 reference

EGF-type aspartate/asparagine hydroxylation site

1 reference

Notch, NODP domain

1 reference

Domain of unknown function DUF3454, notch

1 reference

EGF-like domain

1 reference

ankyrin repeat

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016