RPTOR independent companion of MTOR, complex 2 (Q21985807)

Armadillo-type fold

1 reference

Rapamycin-insensitive companion of mTOR, domain 4, protein family

1 reference

Rapamycin-insensitive companion of mTOR, domain 5, protein family

1 reference

Rapamycin-insensitive companion of mTOR, N-terminal domain, protein family

1 reference

Rapamycin-insensitive companion of mTOR, middle domain, protein family

1 reference

enzyme activator activity

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

8 references

14 February 2019

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

14 February 2019

Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

14 February 2019

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

14 February 2019

mTORC1 promotes survival through translational control of Mcl-1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

14 February 2019

Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

14 February 2019

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

14 February 2019

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

14 February 2019

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

1 reference

14 February 2019

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6QI06&geneProductId=UniProtKB:Q6QI06

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6QI06&geneProductId=UniProtKB:Q6QI06

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6QI06&geneProductId=UniProtKB:Q6QI06

24 April 2018

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6QI06&geneProductId=UniProtKB:Q6QI06

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

14 February 2019

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

regulation of establishment of cell polarity

biological process

1 reference

14 February 2019

Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

regulation of inflammatory response

1 reference

14 February 2019

Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

regulation of protein phosphorylation

1 reference

14 February 2019

mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

actin cytoskeleton reorganization

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

establishment or maintenance of actin cytoskeleton polarity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

regulation of peptidyl-serine phosphorylation

IEA

1 reference

14 February 2019

Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

regulation of gene expression

1 reference

14 February 2019

Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

14 February 2019

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

regulation of GTPase activity

1 reference

14 February 2019

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

positive regulation of actin filament polymerization

1 reference

14 February 2019

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

regulation of protein kinase B signaling

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

14 February 2019

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

positive regulation of catalytic activity

IDA

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

embryo development ending in birth or egg hatching

IEA

1 reference

14 February 2019

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

positive regulation of protein kinase B signaling

3 references

establishment of cell polarity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6QI06

regulation of actin cytoskeleton organization

3 references

regulation of phosphorylation

3 references

Rapamycin-insensitive companion of mTOR, N-terminal domain

1 reference

Rapamycin-insensitive companion of mTOR, domain 4

1 reference

Rapamycin-insensitive companion of mTOR, phosphorylation-site

1 reference

Rapamycin-insensitive companion of mTOR, middle domain

1 reference

Rapamycin-insensitive companion of mTOR, domain 5

1 reference