Msh homeobox 2 (Q21985711)

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox domain, metazoa, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

7 November 2018

Comparison of MSX-1 and MSX-2 suggests a molecular basis for functional redundancy

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03358&geneProductId=UniProtKB:Q03358

transcription factor binding

1 reference

14 January 2019

Structure-function analysis of Msx2-mediated transcriptional suppression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03358&geneProductId=UniProtKB:Q03358

transcription coregulator activity

IPI

1 reference

14 February 2019

The canonical BMP signaling pathway plays a crucial part in stimulation of dentin sialophosphoprotein expression by BMP-2

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

4 references

14 February 2019

The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

14 February 2019

A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

14 February 2019

Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

14 February 2019

Necdin interacts with the Msx2 homeodomain protein via MAGE-D1 to promote myogenic differentiation of C2C12 cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

DNA-binding transcription repressor activity, RNA polymerase II-specific

IPI

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03358&geneProductId=UniProtKB:Q03358

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03358&geneProductId=UniProtKB:Q03358

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

regulation of apoptotic process

TAS

biological process

1 reference

14 February 2019

Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

Msx1 and Msx2 promote meiosis initiation

activation of meiosis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

negative regulation of fat cell differentiation

IPI

1 reference

14 February 2019

Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

negative regulation of keratinocyte differentiation

1 reference

14 February 2019

Accelerated closure of skin wounds in mice deficient in the homeobox gene Msx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

regulation of transcription, DNA-templated

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

mammary gland epithelium development

IEA

1 reference

14 February 2019

Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

branching involved in mammary gland duct morphogenesis

1 reference

14 February 2019

Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

epithelial to mesenchymal transition involved in endocardial cushion formation

1 reference

14 February 2019

Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

wound healing, spreading of epidermal cells

1 reference

14 February 2019

Accelerated closure of skin wounds in mice deficient in the homeobox gene Msx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

cellular response to growth factor stimulus

1 reference

14 February 2019

Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

cellular response to estradiol stimulus

1 reference

14 February 2019

Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

1 reference

14 February 2019

Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

chondrocyte development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

negative regulation of CREB transcription factor activity

1 reference

14 February 2019

Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

outflow tract morphogenesis

1 reference

14 February 2019

Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

signal transduction involved in regulation of gene expression

1 reference

14 February 2019

Msx1 and Msx2 in limb mesenchyme modulate digit number and identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

1 reference

14 February 2019

Accelerated closure of skin wounds in mice deficient in the homeobox gene Msx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

embryonic digit morphogenesis

1 reference

14 February 2019

Msx1 and Msx2 in limb mesenchyme modulate digit number and identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

negative regulation of apoptotic process

1 reference

14 February 2019

Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

bone trabecula formation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

BMP signaling pathway

transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q03358&geneProductId=UniProtKB:Q03358

stem cell differentiation

IEA

1 reference

14 February 2019

Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

outflow tract septum morphogenesis

1 reference

14 February 2019

Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

1 reference

14 February 2019

Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

positive regulation of timing of catagen

1 reference

14 February 2019

Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

positive regulation of mesenchymal cell apoptotic process

IEA

1 reference

14 February 2019

Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

embryonic nail plate morphogenesis

1 reference

14 February 2019

Msx1 and Msx2 in limb mesenchyme modulate digit number and identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

positive regulation of osteoblast differentiation

1 reference

14 February 2019

Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

negative regulation of transcription regulatory region DNA binding

osteoblast differentiation

1 reference

14 February 2019

Bone morphogenetic protein-2-induced alkaline phosphatase expression is stimulated by Dlx5 and repressed by Msx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

frontal suture morphogenesis

1 reference

14 February 2019

Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

positive regulation of BMP signaling pathway

1 reference

14 February 2019

Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

enamel mineralization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

negative regulation of transcription, DNA-templated

1 reference

14 February 2019

Bone morphogenetic protein-2-induced alkaline phosphatase expression is stimulated by Dlx5 and repressed by Msx2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

endochondral bone growth

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

embryonic forelimb morphogenesis

1 reference

14 February 2019

Msx1 and Msx2 in limb mesenchyme modulate digit number and identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

anterior/posterior pattern specification

1 reference

14 February 2019

Msx1 and Msx2 in limb mesenchyme modulate digit number and identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

negative regulation of cell population proliferation

1 reference

14 February 2019

Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

BMP signaling pathway involved in heart development

1 reference

14 February 2019

Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

embryonic hindlimb morphogenesis

1 reference

14 February 2019

Msx1 and Msx2 in limb mesenchyme modulate digit number and identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

osteoblast development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

negative regulation of transcription by RNA polymerase II

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

14 February 2019

Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

14 February 2019

Bone morphogenetic protein-induced MSX1 and MSX2 inhibit myocardin-dependent smooth muscle gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

14 February 2019

Comparison of MSX-1 and MSX-2 suggests a molecular basis for functional redundancy

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

14 February 2019

Structure-function analysis of Msx2-mediated transcriptional suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

14 February 2019

The canonical BMP signaling pathway plays a crucial part in stimulation of dentin sialophosphoprotein expression by BMP-2

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

transcription by RNA polymerase II

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

positive regulation of cell death

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

positive regulation of apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

cartilage development

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

14 February 2019

Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

14 February 2019

Msx2 is a repressor of chondrogenic differentiation in migratory cranial neural crest cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

embryonic morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q03358

1 reference

Homeobox, conserved site

1 reference

stated in

Homeobox domain, metazoa

1 reference

stated in