Msh homeobox 1 (Q21985424)

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox domain, metazoa, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

Murine homeobox-containing gene, Msx-1: analysis of genomic organization, promoter structure, and potential autoregulatory cis-acting elements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

Msx1 is present in thyrotropic cells and binds to a consensus site on the glycoprotein hormone alpha-subunit promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

7 November 2018

Comparison of MSX-1 and MSX-2 suggests a molecular basis for functional redundancy

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13297&geneProductId=UniProtKB:P13297

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

14 February 2019

Msx1 and Msx2 promote meiosis initiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding

1 reference

24 April 2018

Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13297&geneProductId=UniProtKB:P13297

6 references

14 February 2019

Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

YB1/p32, a nuclear Y-box binding protein 1, is a novel regulator of myoblast differentiation that interacts with Msx1 homeoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

Bone morphogenetic protein-induced MSX1 and MSX2 inhibit myocardin-dependent smooth muscle gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

Studies on Pax9-Msx1 protein interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

Necdin interacts with the Msx2 homeodomain protein via MAGE-D1 to promote myogenic differentiation of C2C12 cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

DNA-binding transcription repressor activity, RNA polymerase II-specific

IPI

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

14 February 2019

Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

RNA polymerase II transcription regulatory region sequence-specific DNA binding

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

4 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13297&geneProductId=UniProtKB:P13297

7 November 2018

YB1/p32, a nuclear Y-box binding protein 1, is a novel regulator of myoblast differentiation that interacts with Msx1 homeoprotein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13297&geneProductId=UniProtKB:P13297

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13297&geneProductId=UniProtKB:P13297

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13297&geneProductId=UniProtKB:P13297

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

YB1/p32, a nuclear Y-box binding protein 1, is a novel regulator of myoblast differentiation that interacts with Msx1 homeoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

regulation of odontogenesis

IBA

biological process

1 reference

14 February 2019

Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

roof of mouth development

1 reference

14 February 2019

Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

Msx1 and Msx2 promote meiosis initiation

activation of meiosis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

mesenchymal cell proliferation

1 reference

14 February 2019

BMP4 rescues a non-cell-autonomous function of Msx1 in tooth development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

regulation of transcription, DNA-templated

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

mammary gland epithelium development

1 reference

14 February 2019

Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

epithelial to mesenchymal transition involved in endocardial cushion formation

1 reference

14 February 2019

Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

negative regulation of striated muscle cell differentiation

negative regulation of DNA binding

1 reference

14 February 2019

Bone morphogenetic protein-induced MSX1 and MSX2 inhibit myocardin-dependent smooth muscle gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

3 references

14 February 2019

Msx1 is a regulator of bone formation during development and postnatal growth: in vivo investigations in a transgenic mouse model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis

muscle organ development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

1 reference

14 February 2019

Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

signal transduction involved in regulation of gene expression

1 reference

14 February 2019

Msx1 and Msx2 in limb mesenchyme modulate digit number and identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

embryonic digit morphogenesis

1 reference

14 February 2019

Msx1 and Msx2 in limb mesenchyme modulate digit number and identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

negative regulation of apoptotic process

1 reference

14 February 2019

Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

in utero embryonic development

1 reference

14 February 2019

Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

negative regulation of transcription by RNA polymerase II

8 references

14 February 2019

Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

YB1/p32, a nuclear Y-box binding protein 1, is a novel regulator of myoblast differentiation that interacts with Msx1 homeoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

Bone morphogenetic protein-induced MSX1 and MSX2 inhibit myocardin-dependent smooth muscle gene transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

Comparison of MSX-1 and MSX-2 suggests a molecular basis for functional redundancy

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

YB1/p32, a nuclear Y-box binding protein 1, is a novel regulator of myoblast differentiation that interacts with Msx1 homeoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

Msx1 is present in thyrotropic cells and binds to a consensus site on the glycoprotein hormone alpha-subunit promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

BMP signaling pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13297&geneProductId=UniProtKB:P13297

stem cell differentiation

1 reference

14 February 2019

Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

odontogenesis of dentin-containing tooth

positive regulation of mesenchymal cell apoptotic process

1 reference

14 February 2019

Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

1 reference

14 February 2019

Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

embryonic nail plate morphogenesis

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

A nonsense mutation in MSX1 causes Witkop syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

Msx1 and Msx2 in limb mesenchyme modulate digit number and identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

negative regulation of transcription regulatory region DNA binding

1 reference

14 February 2019

Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation

middle ear morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

epithelial to mesenchymal transition

1 reference

14 February 2019

BMP4 rescues a non-cell-autonomous function of Msx1 in tooth development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

positive regulation of BMP signaling pathway

1 reference

14 February 2019

Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

Msx1 is a regulator of bone formation during development and postnatal growth: in vivo investigations in a transgenic mouse model

cartilage morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

negative regulation of transcription, DNA-templated

1 reference

14 February 2019

MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

embryonic forelimb morphogenesis

1 reference

14 February 2019

Msx1 and Msx2 in limb mesenchyme modulate digit number and identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

A nonsense mutation in MSX1 causes Witkop syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

1 reference

14 February 2019

Msx1 disruption leads to diencephalon defects and hydrocephalus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

anterior/posterior pattern specification

1 reference

14 February 2019

Msx1 and Msx2 in limb mesenchyme modulate digit number and identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

negative regulation of cell population proliferation

1 reference

14 February 2019

Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

positive regulation of transcription by RNA polymerase II

3 references

14 February 2019

Msx1 controls inductive signaling in mammalian tooth morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

Msx1 controls inductive signaling in mammalian tooth morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

14 February 2019

Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

BMP signaling pathway involved in heart development

1 reference

14 February 2019

Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

embryonic hindlimb morphogenesis

1 reference

14 February 2019

Msx1 and Msx2 in limb mesenchyme modulate digit number and identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

cellular response to nicotine

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

transcription by RNA polymerase II

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P13297&geneProductId=UniProtKB:P13297

pituitary gland development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

embryonic morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P13297

1 reference

Homeobox, conserved site

1 reference

stated in

Homeobox domain, metazoa

1 reference

stated in