Homeobox protein OTX2 (Q21985186)

Homeobox-like domain superfamily

1 reference

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Transcription factor Otx, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

9 August 2016

language of work or name

1 reference

9 August 2016

language of work or name

English

molecular function

sequence-specific DNA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

DNA-binding transcription factor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

protein heterodimerization activity

1 reference

9 May 2019

Functional analysis of transcriptional repressor Otx3/Dmbx1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

cis-regulatory region sequence-specific DNA binding

IPI

1 reference

9 May 2019

Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

1 reference

9 May 2019

The subcellular localization of Otx2 is cell-type specific and developmentally regulated in the mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

8 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

9 May 2019

Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

9 May 2019

Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

9 May 2019

The subcellular localization of Otx2 is cell-type specific and developmentally regulated in the mouse retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

9 May 2019

The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

9 May 2019

Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

protein-containing complex

IC

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

transcription regulator complex

1 reference

9 May 2019

Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

metencephalon development

IDA

biological process

1 reference

9 May 2019

Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

1 reference

9 May 2019

Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

dopaminergic neuron differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

1 reference

9 May 2019

Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

1 reference

9 May 2019

Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

regulation of transcription, DNA-templated

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

neuron fate determination

1 reference

9 May 2019

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

positive regulation of gastrulation

1 reference

9 May 2019

Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

anatomical structure development

1 reference

9 May 2019

Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

Otx2 regulates subtype specification and neurogenesis in the midbrain

IDA

cell fate specification

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

somite rostral/caudal axis specification

1 reference

9 May 2019

Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

positive regulation of transcription, DNA-templated

1 reference

9 May 2019

Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

diencephalon morphogenesis

1 reference

9 May 2019

Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

central nervous system development

eye photoreceptor cell fate commitment

1 reference

9 May 2019

Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

Otx1 and Otx2 activities are required for the normal development of the mouse inner ear

inner ear morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

Otx2 regulates subtype specification and neurogenesis in the midbrain

neuron differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

animal organ morphogenesis

1 reference

9 May 2019

Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development

forebrain development

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

9 May 2019

Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

9 May 2019

Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

9 May 2019

Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

positive regulation of embryonic development

1 reference

9 May 2019

Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

dorsal/ventral pattern formation

1 reference

9 May 2019

Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

4 references

9 May 2019

Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

9 May 2019

Otx2 regulates subtype specification and neurogenesis in the midbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

9 May 2019

Regulation of Otx2 expression and its functions in mouse forebrain and midbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

9 May 2019

Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

anterior/posterior pattern specification

3 references

9 May 2019

Murine cerberus homologue mCer-1: a candidate anterior patterning molecule

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

9 May 2019

Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

9 May 2019

Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

positive regulation of transcription by RNA polymerase II

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

9 May 2019

Functional analysis of transcriptional repressor Otx3/Dmbx1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

9 May 2019

Cloning and characterization of mr-s, a novel SAM domain protein, predominantly expressed in retinal photoreceptor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

oligodendrocyte differentiation

IDA

1 reference

9 May 2019

OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

telencephalon regionalization

1 reference

9 May 2019

OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

transcription by RNA polymerase II

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P80206&geneProductId=UniProtKB:P80206

cellular response to leukemia inhibitory factor

1 reference

9 May 2019

miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

protein-containing complex assembly

IEP

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80206

Transcription factor Otx, C-terminal

has part(s)

1 reference

Homeobox domain

1 reference

Homeobox, conserved site

1 reference