Myocyte enhancer factor 2A (Q21985114)

MADS MEF2-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

Holliday junction regulator protein family C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Transcription factor, MADS-box, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Characterization of a cardiac-specific enhancer, which directs {alpha}-cardiac actin gene transcription in the mouse adult heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

transcription coactivator activity

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

sequence-specific DNA binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

RNA polymerase II transcription regulatory region sequence-specific DNA binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

protein dimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

DNA-binding transcription factor activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

DNA-binding transcription activator activity, RNA polymerase II-specific

8 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

21 June 2018

Myospryn is a direct transcriptional target for MEF2A that encodes a striated muscle, alpha-actinin-interacting, costamere-localized protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

21 June 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Myospryn is a direct transcriptional target for MEF2A that encodes a striated muscle, alpha-actinin-interacting, costamere-localized protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

histone deacetylase binding

IC

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Caffeine induces hyperacetylation of histones at the MEF2 site on the Glut4 promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Myospryn is a direct transcriptional target for MEF2A that encodes a striated muscle, alpha-actinin-interacting, costamere-localized protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

RNA polymerase II cis-regulatory region sequence-specific DNA binding

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

21 June 2018

MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

21 June 2018

Promoter architecture of mouse olfactory receptor genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

histone acetyltransferase binding

3 references

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

1 reference

11 October 2018

The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

3 references

protein kinase binding

1 reference

14 February 2019

Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

transcription coactivator activity

IPI

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

RNA polymerase II cis-regulatory region sequence-specific DNA binding

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

MEF2B is a component of a smooth muscle-specific complex that binds an A/T-rich element important for smooth muscle myosin heavy chain gene expression

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Promoter architecture of mouse olfactory receptor genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

DNA-binding transcription activator activity, RNA polymerase II-specific

10 references

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

11 October 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

11 October 2018

Myospryn is a direct transcriptional target for MEF2A that encodes a striated muscle, alpha-actinin-interacting, costamere-localized protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

11 October 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

11 October 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

1 January 2018

Myospryn is a direct transcriptional target for MEF2A that encodes a striated muscle, alpha-actinin-interacting, costamere-localized protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

1 January 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

11 October 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

histone deacetylase binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

DNA-binding transcription factor activity, RNA polymerase II-specific

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

10 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Promoter architecture of mouse olfactory receptor genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Caffeine induces hyperacetylation of histones at the MEF2 site on the Glut4 promoter and increases MEF2A binding to the site via a CaMK-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Characterization of a cardiac-specific enhancer, which directs {alpha}-cardiac actin gene transcription in the mouse adult heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

The expression of MEF2 genes is implicated in CNS neuronal differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

cellular response to calcium ion

biological process

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

regulation of transcription, DNA-templated

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

21 June 2018

Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

21 June 2018

Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

mitochondrial genome maintenance

1 reference

14 February 2019

Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

negative regulation of transcription by RNA polymerase II

3 references

nervous system development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

3 references

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

1 reference

14 February 2019

Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

mitochondrion distribution

1 reference

14 February 2019

Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

ventricular cardiac myofibril assembly

1 reference

14 February 2019

Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

positive regulation of transcription by RNA polymerase II

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

14 February 2019

Myospryn is a direct transcriptional target for MEF2A that encodes a striated muscle, alpha-actinin-interacting, costamere-localized protein

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

transcription by RNA polymerase II

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60929&geneProductId=UniProtKB:Q60929

positive regulation of glucose import

1 reference

14 February 2019

The Krüppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

dendrite morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60929

regulation of transcription, DNA-templated

ISO

Holliday junction regulator protein family C-terminal

has part(s)

1 reference

Transcription factor, MADS-box

1 reference

MADS MEF2-like

1 reference