Receptor-interacting serine-threonine kinase 3 (Q21984804)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Mus musculus

mRIP3
RIP-3
Ripk3
Receptor-interacting protein 3
receptor interacting protein 3
receptor-interacting serine/threonine-protein kinase 3
RIP-like protein kinase 3

Language	Label	Description	Also known as
English	Receptor-interacting serine-threonine kinase 3	mammalian protein found in Mus musculus	mRIP3 RIP-3 Ripk3 Receptor-interacting protein 3 receptor interacting protein 3 receptor-interacting serine/threonine-protein kinase 3 RIP-like protein kinase 3

Statements

1 reference

25 May 2022

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9QZL0

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

RHIM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

nucleotide binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

protein kinase activity

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

kinase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

protein serine/threonine kinase activity

determination method

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Structural insights into RIP3-mediated necroptotic signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

NF-kappaB-inducing kinase activity

determination method

1 reference

14 February 2019

Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

protein binding

determination method

14 references

14 February 2019

PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Structural insights into RIP3-mediated necroptotic signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Daxx is a key downstream component of receptor interacting protein kinase 3 mediating retinal ischemic cell death

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

determination method

2 references

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

plasma membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

intracellular anatomical structure

determination method

1 reference

16 July 2018

Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9QZL0&geneProductId=UniProtKB:Q9QZL0

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

biological process

regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation

determination method

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

amyloid fibril formation

determination method

3 references

T cell differentiation in thymus

determination method

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

programmed cell death

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

phosphorylation

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

protein heterooligomerization

determination method

3 references

thymus development

determination method

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

regulation of interferon-gamma production

determination method

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

positive regulation of oxidoreductase activity

determination method

1 reference

14 February 2019

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

regulation of adaptive immune response

determination method

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

spleen development

determination method

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

regulation of reactive oxygen species metabolic process

determination method

1 reference

14 February 2019

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

regulation of activation-induced cell death of T cells

determination method

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

T cell homeostasis

determination method

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

positive regulation of necroptotic process

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

protein phosphorylation

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

regulation of activated T cell proliferation

determination method

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

positive regulation of reactive oxygen species metabolic process

determination method

protein autophosphorylation

determination method

3 references

positive regulation of ligase activity

determination method

1 reference

14 February 2019

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

determination method

8 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Survival function of the FADD-CASPASE-8-cFLIP(L) complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Caspase 8 inhibits programmed necrosis by processing CYLD

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Mechanisms of necroptosis in T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

regulation of T cell mediated cytotoxicity

determination method

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

14 February 2019

Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

lymph node development

determination method

1 reference

14 February 2019

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

protein homooligomerization

determination method

3 references

activation of protein kinase activity

determination method

3 references

positive regulation of intrinsic apoptotic signaling pathway

determination method

1 reference

14 February 2019

Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

NIK/NF-kappaB signaling

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

positive regulation of necrotic cell death

determination method

1 reference

14 February 2019

Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

cellular response to hydrogen peroxide

determination method

1 reference

14 February 2019

The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

programmed necrotic cell death

determination method

1 reference

14 February 2019

The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QZL0

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000022830

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000022830

ENSMUSP00000126306

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000126306

ENSMUSP00000137278

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000137278

ENSMUSP00000154235

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000154235

ENSMUSP00000153911

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000153911

PDB structure ID

1 reference

UniProt protein ID

10 August 2016

language of work or name

1 reference

UniProt protein ID

10 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21984804&oldid=2023245683"