Forkhead box A2 (Q21983973)

Winged helix-like DNA-binding domain superfamily

1 reference

Fork-head N-terminal domain, protein family

1 reference

Forkhead box protein, C-terminal domain, protein family

1 reference

Fork head domain, protein family

1 reference

Fork head domain conserved site1, protein family

1 reference

Fork head domain conserved site 2, protein family

1 reference

protein domain specific binding

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

DNA-binding transcription activator activity, RNA polymerase II-specific

2 references

10 September 2018

Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35583&geneProductId=UniProtKB:P35583

10 September 2018

Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35583&geneProductId=UniProtKB:P35583

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

transcription factor binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

FoxA proteins regulate H19 endoderm enhancer E1 and exhibit developmental changes in enhancer binding in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Plasticity and expanding complexity of the hepatic transcription factor network during liver development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

DNA-binding transcription factor activity

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

1 reference

9 May 2019

Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

RNA polymerase II cis-regulatory region sequence-specific DNA binding

IPI

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35583&geneProductId=UniProtKB:P35583

double-stranded DNA binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35583&geneProductId=UniProtKB:P35583

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

sequence-specific DNA binding

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Conserved transcriptional regulatory domains of the pdx-1 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35583&geneProductId=UniProtKB:P35583

DNA-binding transcription factor activity, RNA polymerase II-specific

3 references

9 May 2019

Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Conserved transcriptional regulatory domains of the pdx-1 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

DNA-binding transcription activator activity, RNA polymerase II-specific

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

7 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35583&geneProductId=UniProtKB:P35583

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35583&geneProductId=UniProtKB:P35583

24 April 2018

Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35583&geneProductId=UniProtKB:P35583

24 April 2018

Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35583&geneProductId=UniProtKB:P35583

24 April 2018

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35583&geneProductId=UniProtKB:P35583

24 April 2018

Foxa1 and Foxa2 are required for formation of the intervertebral discs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35583&geneProductId=UniProtKB:P35583

24 April 2018

Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35583&geneProductId=UniProtKB:P35583

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

8 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Foxa1 and Foxa2 are required for formation of the intervertebral discs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

transcription regulator complex

1 reference

9 May 2019

Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

biological process

Notch signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

anterior/posterior pattern specification

1 reference

9 May 2019

HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

signal transduction involved in regulation of gene expression

1 reference

9 May 2019

ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

regulation of steroid metabolic process

lung epithelial cell differentiation

1 reference

9 May 2019

Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

regulation of insulin secretion involved in cellular response to glucose stimulus

1 reference

9 May 2019

Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

1 reference

9 May 2019

HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35583&geneProductId=UniProtKB:P35583

1 reference

9 May 2019

Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

multicellular organism development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

response to interleukin-6

1 reference

9 May 2019

A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

anatomical structure morphogenesis

TAS

1 reference

24 April 2018

Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35583&geneProductId=UniProtKB:P35583

positive regulation of gastrulation

1 reference

9 May 2019

Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

positive regulation of embryonic development

1 reference

9 May 2019

Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

regulation of gene expression

1 reference

9 May 2019

Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

adult locomotory behavior

1 reference

9 May 2019

The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

negative regulation of glucokinase activity

1 reference

9 May 2019

Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

positive regulation of transcription from RNA polymerase II promoter by glucose

1 reference

9 May 2019

Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

dorsal/ventral pattern formation

1 reference

9 May 2019

HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

regulation of lipid metabolic process

negative regulation of detection of glucose

1 reference

9 May 2019

Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

epithelial tube branching involved in lung morphogenesis

1 reference

9 May 2019

Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

pattern specification process

1 reference

9 May 2019

HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

in utero embryonic development

1 reference

9 May 2019

Winged-helix, Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sac

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

positive regulation of smoothened signaling pathway

1 reference

9 May 2019

Foxa1 and Foxa2 are required for formation of the intervertebral discs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

1 reference

9 May 2019

Foxa2 is required for the differentiation of pancreatic alpha-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

connective tissue development

1 reference

9 May 2019

Foxa1 and Foxa2 are required for formation of the intervertebral discs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

negative regulation of neuron differentiation

1 reference

9 May 2019

Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

positive regulation of transcription by RNA polymerase III

1 reference

9 May 2019

A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age

cell fate specification

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

dorsal/ventral neural tube patterning

3 references

9 May 2019

Foxa1 and Foxa2 are required for formation of the intervertebral discs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

somite rostral/caudal axis specification

1 reference

9 May 2019

Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

positive regulation of neuron differentiation

3 references

9 May 2019

Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

transcription by RNA polymerase II

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35583&geneProductId=UniProtKB:P35583

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

chromatin organization

1 reference

9 May 2019

regulation of transcription by RNA polymerase II

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35583&geneProductId=UniProtKB:P35583

negative regulation of epithelial to mesenchymal transition

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

regulation of blood coagulation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

negative regulation of DNA-binding transcription factor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

positive regulation of transcription by RNA polymerase II

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Winged-helix, Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sac

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

9 May 2019

Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

negative regulation of transcription from RNA polymerase II promoter by glucose

1 reference

9 May 2019

Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

regulation of transcription, DNA-templated

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development

mesendoderm development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35583

Fork head domain conserved site 2

has part(s)

1 reference

Fork-head N-terminal

1 reference

Fork head domain conserved site1

1 reference

Fork head domain

1 reference

Forkhead box protein, C-terminal

1 reference