Endothelial PAS domain protein 1 (Q21981067)

Hypoxia-inducible factor, alpha subunit

1 reference

PAS domain superfamily

1 reference

Helix-loop-helix DNA-binding domain superfamily

1 reference

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

HIF-1 alpha, transactivation domain, C-terminal domain, protein family

1 reference

PAS fold family

1 reference

PAS fold-3 domain, protein family

1 reference

PAC motif domain, protein family

1 reference

PAS domain, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

protein dimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

DNA-binding transcription activator activity, RNA polymerase II-specific

transcription factor binding

2 references

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

histone acetyltransferase binding

3 references

protein heterodimerization activity

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481

24 April 2018

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481

DNA-binding transcription factor activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

sequence-specific DNA binding

protein heterodimerization activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

Structural integration in hypoxia-inducible factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

transcription regulator complex

cell component

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

5 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481

5 June 2018

Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481

5 June 2018

Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

biological process

surfactant homeostasis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

3 references

14 February 2019

Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

regulation of transcription, DNA-templated

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

1 reference

14 February 2019

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

norepinephrine metabolic process

1 reference

14 February 2019

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

1 reference

14 February 2019

Deletion of HIF-2α in the enterocytes decreases the severity of tissue iron loading in hepcidin knockout mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

mitochondrion organization

IGI

1 reference

14 February 2019

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

embryonic placenta development

1 reference

14 February 2019

Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

1 reference

14 February 2019

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

response to oxidative stress

IGI

transcription, DNA-templated

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

regulation of heart rate

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling

blood vessel remodeling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

4 references

14 February 2019

Endothelium-intrinsic requirement for Hif-2alpha during vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

Retinal disease in mice lacking hypoxia-inducible transcription factor-2alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

erythrocyte differentiation

1 reference

14 February 2019

Acute postnatal ablation of Hif-2alpha results in anemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

cellular response to hypoxia

3 references

positive regulation of transcription by RNA polymerase II

7 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481

5 June 2018

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481

5 June 2018

Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481

5 June 2018

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481

5 June 2018

Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481

5 June 2018

Hypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481

1 reference

14 February 2019

Retinal disease in mice lacking hypoxia-inducible transcription factor-2alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types

myoblast fate commitment

1 reference

14 February 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

regulation of transcription from RNA polymerase II promoter in response to oxidative stress

transcription by RNA polymerase II

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97481&geneProductId=UniProtKB:P97481

negative regulation of transcription by RNA polymerase II

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

norepinephrine biosynthetic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

positive regulation of dopamine biosynthetic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

positive regulation of transcription by RNA polymerase II

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

Hypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

positive regulation of cold-induced thermogenesis

1 reference

14 February 2019

Adipocyte-Specific Hypoxia-Inducible Factor 2α Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97481

Myc-type, basic helix-loop-helix (bHLH) domain

has part(s)

1 reference

PAS fold-3

1 reference

HIF-1 alpha, transactivation domain, C-terminal

1 reference

PAC motif

1 reference

PAS fold

1 reference

PAS domain

1 reference

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016

1 reference

10 August 2016