CCAAT/enhancer binding protein (C/EBP), alpha (Q21499243)

http://www.ebi.ac.uk/interpro/protein/P53566

Basic-leucine zipper domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

DNA-binding transcription activator activity, RNA polymerase II-specific

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

DNA-binding transcription factor activity

5 references

14 February 2019

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

transcription coactivator activity

1 reference

14 February 2019

SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

transcription factor binding

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

6 references

14 February 2019

Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

IPI

1 reference

24 April 2018

Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53566&geneProductId=UniProtKB:P53566

DNA-binding transcription activator activity, RNA polymerase II-specific

2 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53566&geneProductId=UniProtKB:P53566

24 April 2018

C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53566&geneProductId=UniProtKB:P53566

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

Subnuclear localization of C/EBP beta is regulated by growth hormone and dependent on MAPK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

Structural and functional characterization of the mouse p8 gene: promotion of transcription by the CAAT-enhancer binding protein alpha (C/EBPalpha) and C/EBPbeta trans-acting factors involves a C/EBP cis-acting element and other regions of the promo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

Plasticity and expanding complexity of the hepatic transcription factor network during liver development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

protein domain specific binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

histone deacetylase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

protein-containing complex binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

protein heterodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

HMG box domain binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

14 February 2019

Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

Suppression of C/EBP alpha expression in biliary cell differentiation from hepatoblasts during mouse liver development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

protein-containing complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

2 references

transcription regulator complex

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning

biological process

Notch signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

myeloid cell differentiation

1 reference

14 February 2019

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

cellular response to lithium ion

1 reference

14 February 2019

Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

cytokine-mediated signaling pathway

1 reference

14 February 2019

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

1 reference

14 February 2019

Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

regulation of transcription by RNA polymerase II

1 reference

14 February 2019

CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

cellular response to organic cyclic compound

1 reference

14 February 2019

Regulation of Wnt signaling during adipogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

mitochondrion organization

1 reference

14 February 2019

Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

embryonic placenta development

1 reference

14 February 2019

Essential requirement of CCAAT/enhancer binding proteins in embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

cholesterol metabolic process

IGI

1 reference

14 February 2019

Identification of three loci affecting HDL-cholesterol levels in a screen for chemically induced recessive mutations in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

negative regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

negative regulation of cell cycle

1 reference

14 February 2019

Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

1 reference

14 February 2019

C/EBPalpha is required for lung maturation at birth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

transcription, DNA-templated

4 references

14 February 2019

Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

macrophage differentiation

1 reference

14 February 2019

C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

positive regulation of transcription, DNA-templated

1 reference

14 February 2019

Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

positive regulation of osteoblast differentiation

1 reference

14 February 2019

Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

granulocyte differentiation

regulation of cell population proliferation

1 reference

14 February 2019

Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

brown fat cell differentiation

1 reference

14 February 2019

Wdnm1-like, a new adipokine with a role in MMP-2 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

1 reference

14 February 2019

Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

white fat cell differentiation

1 reference

14 February 2019

Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly.

inner ear development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

positive regulation of transcription by RNA polymerase II

4 references

14 February 2019

NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

CAATT/enhancer-binding proteins alpha and delta interact with NKX2-1 to synergistically activate mouse secretoglobin 3A2 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

negative regulation of cell population proliferation

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

C/EBPalpha deficiency results in hyperproliferation of hematopoietic progenitor cells and disrupts macrophage development in vitro and in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

cellular response to tumor necrosis factor

1 reference

14 February 2019

Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

transcription by RNA polymerase II

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53566&geneProductId=UniProtKB:P53566

positive regulation of DNA-templated transcription, initiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

regulation of transcription, DNA-templated

fat cell differentiation

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

14 February 2019

Mitotic clonal expansion: a synchronous process required for adipogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

transcription by RNA polymerase I

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

positive regulation of macrophage activation

1 reference

14 February 2019

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

positive regulation of inflammatory response

1 reference

14 February 2019

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53566

interleukin-6-mediated signaling pathway

1 reference

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53566&geneProductId=UniProtKB:P53566

Basic-leucine zipper domain

has part(s)

1 reference

stated in

InterPro Release 71.0