SUFU negative regulator of hedgehog signaling (Q21495920)

Suppressor of fused, N-terminal

1 reference

Suppressor of fused, C-terminal domain superfamily

1 reference

Suppressor of fused-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Suppressor of fused C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

Suppressor of fused negatively regulates beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

7 references

14 February 2019

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

GSK3beta positively regulates Hedgehog signaling through Sufu in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

The Suppressor of fused gene, involved in Hedgehog signal transduction in Drosophila, is conserved in mammals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

transcription corepressor activity

IPI

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

signal transducer activity

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

transcription factor binding

4 references

14 February 2019

Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

6 references

21 June 2018

Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

21 June 2018

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

21 June 2018

Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

21 June 2018

Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

3 references

14 February 2019

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

21 June 2018

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

5 references

14 February 2019

Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

ventricular septum development

biological process

1 reference

14 February 2019

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

smoothened signaling pathway involved in ventral spinal cord interneuron specification

1 reference

14 February 2019

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

cytoplasmic sequestering of transcription factor

1 reference

21 June 2018

Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

IGI

1 reference

14 February 2019

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

spinal cord dorsal/ventral patterning

1 reference

14 February 2019

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

negative regulation of transcription by RNA polymerase II

3 references

14 February 2019

Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

coronary vasculature development

IDA

1 reference

14 February 2019

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

1 reference

14 February 2019

Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

1 reference

14 February 2019

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

1 reference

14 February 2019

Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

determination of left/right symmetry

1 reference

14 February 2019

Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

smoothened signaling pathway involved in spinal cord motor neuron cell fate specification

1 reference

14 February 2019

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

negative regulation of ubiquitin-dependent protein catabolic process

1 reference

14 February 2019

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

1 reference

14 February 2019

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

negative regulation of DNA-binding transcription factor activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

negative regulation of smoothened signaling pathway

4 references

24 April 2018

Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

24 April 2018

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

24 April 2018

Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

negative regulation of smoothened signaling pathway

IDA

5 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

21 June 2018

Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

21 June 2018

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

21 June 2018

Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z0P7&geneProductId=UniProtKB:Q9Z0P7

negative regulation of smoothened signaling pathway

IDA

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z0P7

Suppressor of fused C-terminal

IEA

has part(s)

1 reference

Suppressor of fused-like domain

1 reference