Hes family bHLH transcription factor 7 (Q21495819)

Helix-loop-helix DNA-binding domain superfamily

1 reference

stated in

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Orange domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

transcription factor binding

1 reference

9 May 2019

Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

protein dimerization activity

NAS

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

RNA polymerase II transcription regulatory region sequence-specific DNA binding

IEA

1 reference

27 March 2018

Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BKT2&geneProductId=UniProtKB:Q8BKT2

DNA-binding transcription repressor activity, RNA polymerase II-specific

IDA

1 reference

14 February 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

RNA polymerase II transcription regulatory region sequence-specific DNA binding

IC

DNA-binding transcription repressor activity, RNA polymerase II-specific

IDA

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BKT2&geneProductId=UniProtKB:Q8BKT2

transcription corepressor activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

transcription factor binding

sequence-specific DNA binding

NAS

2 references

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

sequence-specific double-stranded DNA binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

3 references

9 May 2019

Instability of Hes7 protein is crucial for the somite segmentation clock

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

9 May 2019

Dynamic expression and essential functions of Hes7 in somite segmentation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

9 May 2019

Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

multicellular organism development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

post-anal tail morphogenesis

IEA

1 reference

9 May 2019

Dynamic expression and essential functions of Hes7 in somite segmentation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

skeletal system development

1 reference

9 May 2019

Dynamic expression and essential functions of Hes7 in somite segmentation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

regulation of transcription, DNA-templated

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

negative regulation of transcription by RNA polymerase II

IEA

5 references

14 February 2019

The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

14 February 2019

Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

14 February 2019

Instability of Hes7 protein is crucial for the somite segmentation clock

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

14 February 2019

The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

regulation of somitogenesis

IDA

1 reference

14 February 2019

Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

transcription, DNA-templated

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8BKT2&geneProductId=UniProtKB:Q8BKT2

3 references

14 February 2019

Instability of Hes7 protein is crucial for the somite segmentation clock

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

14 February 2019

Dynamic expression and essential functions of Hes7 in somite segmentation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

Notch signaling pathway

3 references

14 February 2019

14 February 2019

Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

regulation of neurogenesis

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

negative regulation of transcription by RNA polymerase II

6 references

9 May 2019

The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

9 May 2019

Instability of Hes7 protein is crucial for the somite segmentation clock

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

9 May 2019

Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

9 May 2019

The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

anterior/posterior pattern specification

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8BKT2

1 reference

Myc-type, basic helix-loop-helix (bHLH) domain

1 reference

stated in