Cadherin, EGF LAG seven-pass G-type receptor 1 (Q21494076)

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mammalian protein found in Mus musculus

cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
cadherin EGF LAG seven-pass G-type receptor 1
Celsr1
seven-pass transmembrane receptor

Language	Label	Description	Also known as
English	Cadherin, EGF LAG seven-pass G-type receptor 1	mammalian protein found in Mus musculus	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila) cadherin EGF LAG seven-pass G-type receptor 1 Celsr1 seven-pass transmembrane receptor

Statements

1 reference

25 May 2022

UniProt protein ID

Cadherin-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35161

Concanavalin A-like lectin/glucanase domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35161

Growth factor receptor cysteine-rich domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35161

GPCR, family 2, secretin-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35161

GPCR family 2, extracellular hormone receptor domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35161

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

GPCR, family 2, extracellular hormone receptor domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Laminin G domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

GPCR, family 2-like

1 reference

based on heuristic

inferred from protein domain or family

GPS motif domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Laminin EGF domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like calcium-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

GAIN domain, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cadherin-like, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cadherin conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

signal transducer activity

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35161&geneProductId=UniProtKB:O35161

determination method

protein dimerization activity

determination method

1 reference

9 May 2019

Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

G protein-coupled receptor activity

determination method

3 references

9 May 2019

Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

integral component of plasma membrane

determination method

1 reference

9 May 2019

Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

determination method

plasma membrane

determination method

4 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

biological process

establishment of planar polarity

determination method

1 reference

9 May 2019

Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

gastrulation with mouth forming second

determination method

1 reference

9 May 2019

Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

cell-cell signaling

determination method

1 reference

9 May 2019

Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

determination method

1 reference

9 May 2019

Epidermal wound repair is regulated by the planar cell polarity signaling pathway

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

multicellular organism development

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

hair follicle development

determination method

1 reference

9 May 2019

Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

homophilic cell adhesion via plasma membrane adhesion molecules

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

regulation of actin cytoskeleton organization

determination method

1 reference

9 May 2019

The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

regulation of neurotransmitter secretion

determination method

1 reference

9 May 2019

Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

locomotory behavior

determination method

1 reference

9 May 2019

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

inner ear morphogenesis

determination method

1 reference

9 May 2019

Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

protein localization involved in establishment of planar polarity

determination method

1 reference

9 May 2019

Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

G protein-coupled receptor signaling pathway

determination method

3 references

9 May 2019

Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

planar dichotomous subdivision of terminal units involved in lung branching morphogenesis

determination method

1 reference

9 May 2019

The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

cell surface receptor signaling pathway

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

central nervous system development

determination method

1 reference

9 May 2019

Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

apical protein localization

determination method

1 reference

9 May 2019

Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

lateral sprouting involved in lung morphogenesis

determination method

1 reference

9 May 2019

The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

planar cell polarity pathway involved in neural tube closure

determination method

1 reference

9 May 2019

The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis

determination method

1 reference

9 May 2019

The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

Rho protein signal transduction

determination method

1 reference

9 May 2019

The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

establishment of planar polarity of embryonic epithelium

determination method

1 reference

9 May 2019

Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

neuron migration

determination method

1 reference

9 May 2019

Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

cell-cell adhesion

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35161

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35161

GPCR, family 2-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35161

Cadherin conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35161

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35161

GPCR, family 2, extracellular hormone receptor domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35161

Laminin G domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35161

EGF-like calcium-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35161

EGF-like, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35161

GAIN domain, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35161

EGF-type aspartate/asparagine hydroxylation site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35161

EGF-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35161

Laminin EGF domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35161

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000016172

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000016172

ENSMUSP00000154168

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000154168

ENSMUSP00000153927

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000153927

ENSMUSP00000159344

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000159344

ENSMUSP00000159353

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000159353

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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