Frizzled class receptor 1 (Q21204094)

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mammalian protein found in Homo sapiens

FZD1
frizzled family receptor 1
fzE1
frizzled homolog 1
Wnt receptor
frizzled 1, seven transmembrane spanning receptor
frizzled-1
fz-1
frizzled, Drosophila, homolog of, 1
hFz1

Language	Label	Description	Also known as
English	Frizzled class receptor 1	mammalian protein found in Homo sapiens	FZD1 frizzled family receptor 1 fzE1 frizzled homolog 1 Wnt receptor frizzled 1, seven transmembrane spanning receptor frizzled-1 fz-1 frizzled, Drosophila, homolog of, 1 hFz1

Statements

1 reference

13 November 2019

UniProt protein ID

Frizzled cysteine-rich domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UP38

G protein-coupled receptor

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Frizzled/Smoothened, transmembrane domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

GPCR, family 2-like

1 reference

based on heuristic

inferred from protein domain or family

Frizzled domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

PDZ domain binding

determination method

1 reference

1 January 2018

Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

frizzled binding

determination method

1 reference

1 January 2018

Myocilin is a modulator of Wnt signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

signal transducer activity

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

determination method

Wnt-protein binding

determination method

4 references

17 October 2017

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

determination method

17 October 2017

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

determination method

17 October 2017

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

determination method

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

determination method

protein binding

determination method

1 reference

1 January 2018

Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

Wnt-activated receptor activity

determination method

5 references

17 October 2017

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

determination method

17 October 2017

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

determination method

17 October 2017

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

determination method

17 October 2017

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

determination method

signaling receptor binding

determination method

1 reference

1 January 2018

The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

transmembrane signaling receptor activity

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

G protein-coupled receptor activity

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

Wnt-protein binding

determination method

5 references

1 January 2018

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

1 January 2018

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

1 January 2018

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

Wnt-activated receptor activity

determination method

6 references

1 January 2018

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

1 January 2018

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

1 January 2018

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

1 January 2018

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

Wnt signalosome

determination method

1 reference

1 January 2018

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

determination method

2 references

determination method

1 reference

17 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

determination method

determination method

1 reference

1 January 2018

A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5)

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

integral component of membrane

determination method

plasma membrane

determination method

determination method

1 reference

1 January 2018

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

biological process

G protein-coupled receptor signaling pathway

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

positive regulation of protein phosphorylation

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

autocrine signaling

determination method

1 reference

1 January 2018

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

epithelial cell differentiation

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

muscular septum morphogenesis

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

ventricular septum morphogenesis

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

membranous septum morphogenesis

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

outflow tract morphogenesis

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

positive regulation of DNA-binding transcription factor activity

determination method

Wnt signaling pathway

determination method

2 references

planar cell polarity pathway involved in neural tube closure

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

negative regulation of BMP signaling pathway

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

1 January 2018

Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

multicellular organism development

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

cell surface receptor signaling pathway

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation

determination method

1 reference

1 January 2018

Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

canonical Wnt signaling pathway involved in osteoblast differentiation

determination method

1 reference

1 January 2018

Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

hard palate development

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

neuron differentiation

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

canonical Wnt signaling pathway

determination method

6 references

17 October 2017

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

determination method

17 October 2017

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

determination method

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

determination method

17 October 2017

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

determination method

17 October 2017

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

determination method

17 October 2017

The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UP38&geneProductId=UniProtKB:Q9UP38

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

signal transduction

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation

determination method

1 reference

1 January 2018

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

beta-catenin destruction complex disassembly

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

Wnt signaling pathway, planar cell polarity pathway

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

presynapse assembly

determination method

1 reference

1 January 2018

Dysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

negative regulation of oxidative stress-induced neuron death

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

non-canonical Wnt signaling pathway

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

positive regulation of neuron projection development

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

canonical Wnt signaling pathway

determination method

7 references

1 January 2018

Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

1 January 2018

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

1 January 2018

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

1 January 2018

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

1 January 2018

The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

negative regulation of canonical Wnt signaling pathway

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

regulation of presynapse assembly

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UP38

determination method

frizzled domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UP38

GPCR, family 2-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UP38

Frizzled/Smoothened, transmembrane domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UP38

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000287934

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000287934

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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