Centromere protein J (Q21173229)

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mammalian protein found in Homo sapiens

centromere protein J
LAG-3-associated protein
LYST-interacting protein 1
centrosomal P4.1-associated protein
Spindle assembly abnormal 4
CENPJ
LYST-interacting protein LIP1
LYST-interacting protein LIP7

Language	Label	Description	Also known as
English	Centromere protein J	mammalian protein found in Homo sapiens	centromere protein J LAG-3-associated protein LYST-interacting protein 1 centrosomal P4.1-associated protein Spindle assembly abnormal 4 CENPJ LYST-interacting protein LIP1 LYST-interacting protein LIP7

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

Centromere protein J

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9HC77

T-complex protein 10, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

12 references

9 May 2019

Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the gamma-tubulin complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

9 May 2019

RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

9 May 2019

Asterless is a scaffold for the onset of centriole assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

9 May 2019

Structural Analysis of the G-Box Domain of the Microcephaly Protein CPAP Suggests a Role in Centriole Architecture

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

9 May 2019

PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

9 May 2019

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

9 May 2019

A human MAP kinase interactome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

9 May 2019

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

9 May 2019

Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

9 May 2019

CPAP interacts with 14-3-3 in a cell cycle-dependent manner

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

9 May 2019

The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

9 May 2019

Tankyrase 1 regulates centrosome function by controlling CPAP stability

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

protein kinase binding

determination method

1 reference

9 May 2019

PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

protein domain specific binding

determination method

1 reference

9 May 2019

The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

identical protein binding

determination method

1 reference

9 May 2019

Structural Analysis of the G-Box Domain of the Microcephaly Protein CPAP Suggests a Role in Centriole Architecture

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

transcription corepressor activity

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

microtubule organizing center

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

gamma-tubulin small complex

determination method

1 reference

9 May 2019

Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the gamma-tubulin complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

determination method

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

8 April 2019

PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

8 April 2019

Plk4-induced centriole biogenesis in human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

8 April 2019

The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

determination method

1 reference

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

plasma membrane

determination method

1 reference

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

ciliary basal body

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

determination method

7 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

9 May 2019

Plk4-induced centriole biogenesis in human cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

9 May 2019

The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

9 May 2019

PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

biological process

microtubule polymerization

determination method

1 reference

9 May 2019

Identification of a novel microtubule-destabilizing motif in CPAP that binds to tubulin heterodimers and inhibits microtubule assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

G2/M transition of mitotic cell cycle

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

microtubule nucleation

determination method

1 reference

9 May 2019

Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the gamma-tubulin complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

centriole elongation

determination method

1 reference

9 May 2019

The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

ciliary basal body-plasma membrane docking

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

regulation of G2/M transition of mitotic cell cycle

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

smoothened signaling pathway

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

motile cilium assembly

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

centrosome duplication

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

centriole assembly

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

positive regulation of non-motile cilium assembly

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

non-motile cilium assembly

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

positive regulation of centriole elongation

determination method

1 reference

9 May 2019

CEP295 interacts with microtubules and is required for centriole elongation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

positive regulation of establishment of protein localization

determination method

1 reference

9 May 2019

CEP295 interacts with microtubules and is required for centriole elongation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

negative regulation of nucleic acid-templated transcription

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HC77

determination method

T-complex protein 10, C-terminal domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9HC77

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000371308

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000371308

ENSP00000477511

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000477511

ENSP00000399334

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000399334

ENSP00000441090

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000441090

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wiktionary(0 entries)

Multilingual sites(0 entries)

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