Rho/Rac guanine nucleotide exchange factor 2 (Q21171608)

http://www.ebi.ac.uk/interpro/protein/Q92974

PH-like domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92974

membrane protein

1 reference

inferred from GOA cell component → membrane

pleckstrin homology domain, protein family

1 reference

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family

1 reference

ARHGEF2, PH domain, protein family

1 reference

Dbl homology (DH) domain, protein family

1 reference

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

transcription factor binding

NAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

6 references

8 April 2019

GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

8 April 2019

Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

8 April 2019

p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

8 April 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

guanyl-nucleotide exchange factor activity

IPI

1 reference

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

1 reference

31 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92974&geneProductId=UniProtKB:Q92974

bicellular tight junction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

protein-containing complex

HDA

1 reference

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

postsynaptic density, intracellular component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

intracellular signal transduction

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

negative regulation of necroptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

immune system process

1 reference

8 April 2019

negative regulation of neurogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

cellular response to tumor necrosis factor

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

cellular response to muramyl dipeptide

1 reference

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

cellular hyperosmotic response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

negative regulation of microtubule depolymerization

1 reference

8 April 2019

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

regulation of cell population proliferation

IMP

1 reference

8 April 2019

Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

establishment of mitotic spindle orientation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

positive regulation of interleukin-6 production

1 reference

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

positive regulation of tumor necrosis factor production

1 reference

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

positive regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

regulation of Rho protein signal transduction

3 references

8 April 2019

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

intracellular protein transport

1 reference

8 April 2019

Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

NAS

innate immune response

1 reference

8 April 2019

regulation of small GTPase mediated signal transduction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

negative regulation of podosome assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

multicellular organism development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

nervous system development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92974