Secreted frizzled related protein 5 (Q21159912)

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mammalian protein found in Homo sapiens

secreted frizzled-related protein 5
frizzled-related protein 1b
FRP-1b
sFRP-5
SARP-3
secreted apoptosis related protein 3
SFRP5
Secreted apoptosis-related protein 3

Language	Label	Description	Also known as
English	Secreted frizzled related protein 5	mammalian protein found in Homo sapiens	secreted frizzled-related protein 5 frizzled-related protein 1b FRP-1b sFRP-5 SARP-3 secreted apoptosis related protein 3 SFRP5 Secreted apoptosis-related protein 3

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

Tissue inhibitor of metalloproteinases-like, OB-fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q5T4F7

Secreted frizzled-related protein 5

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q5T4F7

Frizzled cysteine-rich domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q5T4F7

Frizzled domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Netrin module, non-TIMP type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Netrin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

G protein-coupled receptor activity

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5T4F7&geneProductId=UniProtKB:Q5T4F7

determination method

Wnt-activated receptor activity

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5T4F7&geneProductId=UniProtKB:Q5T4F7

determination method

extracellular region

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T4F7

determination method

extracellular space

determination method

1 reference

27 March 2018

Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5T4F7&geneProductId=UniProtKB:Q5T4F7

determination method

integral component of membrane

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5T4F7&geneProductId=UniProtKB:Q5T4F7

determination method

biological process

cell differentiation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T4F7

determination method

negative regulation of protein kinase B signaling

determination method

1 reference

8 April 2019

Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T4F7

determination method

negative regulation of Wnt signaling pathway

determination method

1 reference

8 April 2019

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T4F7

determination method

anatomical structure morphogenesis

determination method

1 reference

8 April 2019

Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T4F7

determination method

Wnt signaling pathway

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T4F7

determination method

negative regulation of DNA-binding transcription factor activity

determination method

1 reference

8 April 2019

Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T4F7

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T4F7

determination method

establishment or maintenance of cell polarity

determination method

1 reference

8 April 2019

Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T4F7

determination method

negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis

determination method

1 reference

8 April 2019

Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T4F7

determination method

negative regulation of canonical Wnt signaling pathway

determination method

1 reference

27 March 2018

Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5T4F7&geneProductId=UniProtKB:Q5T4F7

determination method

signal transduction

determination method

1 reference

8 April 2019

Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T4F7

determination method

visual perception

determination method

1 reference

8 April 2019

Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T4F7

determination method

negative regulation of cell population proliferation

determination method

1 reference

8 April 2019

Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T4F7

determination method

apoptotic process

determination method

1 reference

8 April 2019

SARPs: a family of secreted apoptosis-related proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T4F7

determination method

regulation of Wnt signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T4F7

determination method

regulation of BMP signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T4F7

determination method

G protein-coupled receptor signaling pathway

determination method

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5T4F7&geneProductId=UniProtKB:Q5T4F7

determination method

non-canonical Wnt signaling pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T4F7

determination method

canonical Wnt signaling pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T4F7

determination method

negative regulation of canonical Wnt signaling pathway

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q5T4F7

Netrin module, non-TIMP type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q5T4F7

frizzled domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q5T4F7

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000266066

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000266066

Sitelinks

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Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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