DNA-(apurinic or apyrimidinic site) lyase (Q21137455)

http://www.ebi.ac.uk/interpro/protein/G3V3M6

http://www.ebi.ac.uk/interpro/protein/P27695

Endonuclease/exonuclease/phosphatase superfamily

2 references

http://www.ebi.ac.uk/interpro/protein/G3V3M6

http://www.ebi.ac.uk/interpro/protein/P27695

Endonuclease/exonuclease/phosphatase family

1 reference

based on heuristic

inferred from protein domain or family

AP endonuclease 1, binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

AP endonuclease 1, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

2 references

17 September 2016

13 November 2019

2 references

20 March 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:G3V3M6

13 November 2019

2 references

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:G3V3M6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:G3V3M6

17 references

8 April 2019

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Identification and characterization of mitochondrial targeting sequence of human apurinic/apyrimidinic endonuclease 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

SIRT1 deacetylates APE1 and regulates cellular base excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Human ribosomal protein S3 interacts with DNA base excision repair proteins hAPE/Ref-1 and hOGG1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

A multiprotein complex necessary for both transcription and DNA replication at the β-globin locus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

SIRT1 deacetylates APE1 and regulates cellular base excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

phosphodiesterase I activity

1 reference

17 October 2017

Identification of redox/repair protein Ref-1 as a potent activator of p53

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27695&geneProductId=UniProtKB:P27695

double-stranded DNA 3'-5' exodeoxyribonuclease activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter

IBA

chromatin DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

endoribonuclease activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

uracil DNA N-glycosylase activity

1 reference

8 April 2019

Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

phosphoric diester hydrolase activity

double-stranded telomeric DNA binding

1 reference

8 April 2019

APE1 incision activity at abasic sites in tandem repeat sequences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

double-stranded DNA exodeoxyribonuclease activity

1 reference

8 April 2019

APE1 incision activity at abasic sites in tandem repeat sequences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

transcription coactivator activity

1 reference

8 April 2019

Identification of redox/repair protein Ref-1 as a potent activator of p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

RNA-DNA hybrid ribonuclease activity

1 reference

8 April 2019

Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

3 references

8 April 2019

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Characterization of human ribosomal protein S3 binding to 7,8-dihydro-8-oxoguanine and abasic sites by surface plasmon resonance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

APE1 incision activity at abasic sites in tandem repeat sequences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

transcription corepressor activity

1 reference

8 April 2019

A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

3'-5' exonuclease activity

DNA-(apurinic or apyrimidinic site) endonuclease activity

7 references

17 October 2017

Identification of redox/repair protein Ref-1 as a potent activator of p53

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27695&geneProductId=UniProtKB:P27695

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27695&geneProductId=UniProtKB:P27695

17 October 2017

Human ribosomal protein S3 (hRpS3) interacts with uracil-DNA glycosylase (hUNG) and stimulates its glycosylase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27695&geneProductId=UniProtKB:P27695

17 October 2017

Characterization of a wide range base-damage-endonuclease activity of mammalian rpS3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27695&geneProductId=UniProtKB:P27695

17 October 2017

APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27695&geneProductId=UniProtKB:P27695

17 October 2017

Drosophila ribosomal protein PO contains apurinic/apyrimidinic endonuclease activity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27695&geneProductId=UniProtKB:P27695

17 October 2017

APE1 incision activity at abasic sites in tandem repeat sequences

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27695&geneProductId=UniProtKB:P27695

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

endonuclease activity

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Sequence analysis identifies TTRAP, a protein that associates with CD40 and TNF receptor-associated factors, as a member of a superfamily of divalent cation-dependent phosphodiesterases

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27695&geneProductId=UniProtKB:P27695

DNA-(apurinic or apyrimidinic site) endonuclease activity

7 references

8 April 2019

Identification of redox/repair protein Ref-1 as a potent activator of p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Human ribosomal protein S3 (hRpS3) interacts with uracil-DNA glycosylase (hUNG) and stimulates its glycosylase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Characterization of a wide range base-damage-endonuclease activity of mammalian rpS3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Drosophila ribosomal protein PO contains apurinic/apyrimidinic endonuclease activity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

APE1 incision activity at abasic sites in tandem repeat sequences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:G3V3M6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:G3V3M6

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:G3V3M6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:G3V3M6

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27695&geneProductId=UniProtKB:P27695

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27695&geneProductId=UniProtKB:P27695

17 October 2017

SIRT1 deacetylates APE1 and regulates cellular base excision repair

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27695&geneProductId=UniProtKB:P27695

17 October 2017

Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1).

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27695&geneProductId=UniProtKB:P27695

17 October 2017

Identification of redox/repair protein Ref-1 as a potent activator of p53

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27695&geneProductId=UniProtKB:P27695

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27695&geneProductId=UniProtKB:P27695

perinuclear region of cytoplasm

1 reference

8 April 2019

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

1 reference

8 April 2019

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

transcription regulator complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Identification and characterization of mitochondrial targeting sequence of human apurinic/apyrimidinic endonuclease 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Identification of redox/repair protein Ref-1 as a potent activator of p53

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

SIRT1 deacetylates APE1 and regulates cellular base excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1).

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

positive regulation of G1/S transition of mitotic cell cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

negative regulation of smooth muscle cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

regulation of transcription, DNA-templated

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27695&geneProductId=UniProtKB:P27695

1 reference

8 April 2019

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

cellular response to cAMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

RNA phosphodiester bond hydrolysis, endonucleolytic

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

transcription, DNA-templated

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27695&geneProductId=UniProtKB:P27695

response to organonitrogen compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

cellular response to hydrogen peroxide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

cellular response to peptide hormone stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

regulation of mRNA stability

1 reference

8 April 2019

Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

cellular response to organonitrogen compound

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

cell redox homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

1 reference

8 April 2019

APE1 incision activity at abasic sites in tandem repeat sequences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

negative regulation of nucleic acid-templated transcription

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

telomere maintenance via base-excision repair

1 reference

8 April 2019

APE1 incision activity at abasic sites in tandem repeat sequences

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

regulation of apoptotic process

1 reference

8 April 2019

SIRT1 deacetylates APE1 and regulates cellular base excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Drosophila ribosomal protein PO contains apurinic/apyrimidinic endonuclease activity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

positive regulation of nucleic acid-templated transcription

IBA

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27695

Identifiers

MeSH descriptor ID

C085108

subject named as

APEX1 protein, human

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

20 March 2016

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference