VPS26, retromer complex component A (Q21136427)

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mammalian protein found in Homo sapiens

vacuolar protein sorting 26 homolog A
vacuolar protein sorting-associated protein 26A
VPS26A
vesicle protein sorting 26A
hVPS26
VPS26 retromer complex comonent A

Language	Label	Description	Also known as
English	VPS26, retromer complex component A	mammalian protein found in Homo sapiens	vacuolar protein sorting 26 homolog A vacuolar protein sorting-associated protein 26A VPS26A vesicle protein sorting 26A hVPS26 VPS26 retromer complex comonent A

Statements

1 reference

13 November 2019

UniProt protein ID

Vacuolar protein sorting protein 26 related

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75436

Arrestin, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75436

transporter of unknown biochemical mechanism

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

11 references

9 May 2019

The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Functional architecture of the retromer cargo-recognition complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Pharmacological chaperones stabilize retromer to limit APP processing

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

tubular endosome

determination method

1 reference

9 May 2019

Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

retromer complex

determination method

3 references

27 March 2018

Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75436&geneProductId=UniProtKB:O75436

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75436&geneProductId=UniProtKB:O75436

determination method

27 March 2018

Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75436&geneProductId=UniProtKB:O75436

determination method

determination method

1 reference

9 May 2019

A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

determination method

4 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75436&geneProductId=UniProtKB:O75436

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75436&geneProductId=UniProtKB:O75436

determination method

27 March 2018

A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75436&geneProductId=UniProtKB:O75436

determination method

27 March 2018

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75436&geneProductId=UniProtKB:O75436

determination method

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

determination method

1 reference

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

endosome membrane

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

retromer, cargo-selective complex

determination method

determination method

5 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

retromer complex

determination method

5 references

9 May 2019

Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

biological process

protein transport

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

retrograde transport, endosome to Golgi

determination method

4 references

27 March 2018

Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75436&geneProductId=UniProtKB:O75436

determination method

27 March 2018

Retromer: Structure, function, and roles in mammalian disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75436&geneProductId=UniProtKB:O75436

determination method

27 March 2018

Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75436&geneProductId=UniProtKB:O75436

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75436&geneProductId=UniProtKB:O75436

determination method

regulation of macroautophagy

determination method

1 reference

9 May 2019

Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

intracellular protein transport

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

Wnt signaling pathway

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

signal transduction

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75436&geneProductId=UniProtKB:O75436

determination method

retrograde transport, endosome to Golgi

determination method

5 references

9 May 2019

Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Retromer: Structure, function, and roles in mammalian disease

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75436

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000263559

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000263559

ENSP00000362480

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000362480

ENSP00000378532

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378532

ENSP00000473746

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000473746

ENSP00000474611

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000474611

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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