SMG1 nonsense mediated mRNA decay associated PI3K related kinase (Q21134874)

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mammalian protein found in Homo sapiens
  • PI-3-kinase-related kinase SMG-1
  • lambda/iota protein kinase C-interacting protein
  • 61E3.4
  • lambda-interacting protein
  • smg-1 homolog, phosphatidylinositol 3-kinase-related kinase
  • SMG1
  • serine/threonine-protein kinase SMG1
  • SMG1 phosphatidylinositol 3-kinase-related kinase
edit
Language Label Description Also known as
English
SMG1 nonsense mediated mRNA decay associated PI3K related kinase
mammalian protein found in Homo sapiens
  • PI-3-kinase-related kinase SMG-1
  • lambda/iota protein kinase C-interacting protein
  • 61E3.4
  • lambda-interacting protein
  • smg-1 homolog, phosphatidylinositol 3-kinase-related kinase
  • SMG1
  • serine/threonine-protein kinase SMG1
  • SMG1 phosphatidylinositol 3-kinase-related kinase

Statements

molecular function
protein binding
determination method
IPI
7 references
retrieved
8 April 2019
stated in
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
IPI
retrieved
8 April 2019
stated in
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
IPI
retrieved
8 April 2019
stated in
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
IPI
retrieved
8 April 2019
stated in
AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
IPI
retrieved
8 April 2019
stated in
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
IPI
retrieved
8 April 2019
stated in
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
IPI
retrieved
8 April 2019
stated in
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
IPI
protein serine/threonine kinase activity
determination method
IEA
NAS
EXP
IDA
7 references
retrieved
26 September 2017
stated in
Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96Q15&geneProductId=UniProtKB:Q96Q15
determination method
NAS
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96Q15&geneProductId=UniProtKB:Q96Q15
determination method
IEA
retrieved
26 September 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96Q15&geneProductId=UniProtKB:Q96Q15
determination method
IEA
retrieved
26 September 2017
stated in
The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96Q15&geneProductId=UniProtKB:Q96Q15
determination method
IDA
retrieved
26 September 2017
stated in
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96Q15&geneProductId=UniProtKB:Q96Q15
determination method
IDA
retrieved
26 September 2017
stated in
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96Q15&geneProductId=UniProtKB:Q96Q15
determination method
IDA
retrieved
26 September 2017
stated in
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96Q15&geneProductId=UniProtKB:Q96Q15
determination method
EXP
protein serine/threonine kinase activity
determination method
EXP
IBA
IDA
IEA
NAS
8 references
retrieved
8 April 2019
stated in
Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
IEA
retrieved
8 April 2019
stated in
The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
IDA
retrieved
8 April 2019
stated in
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
IDA
retrieved
8 April 2019
stated in
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
IBA
retrieved
8 April 2019
stated in
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
EXP
cell component
biological process
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
determination method
IEA
NAS
IDA
TAS
6 references
retrieved
26 September 2017
stated in
The human RNA surveillance factor UPF1 is required for S phase progression and genome stability
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96Q15&geneProductId=UniProtKB:Q96Q15
determination method
TAS
retrieved
26 September 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96Q15&geneProductId=UniProtKB:Q96Q15
determination method
TAS
retrieved
26 September 2017
stated in
Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96Q15&geneProductId=UniProtKB:Q96Q15
determination method
NAS
retrieved
26 September 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96Q15&geneProductId=UniProtKB:Q96Q15
determination method
IEA
retrieved
26 September 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96Q15&geneProductId=UniProtKB:Q96Q15
determination method
IEA
retrieved
26 September 2017
stated in
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96Q15&geneProductId=UniProtKB:Q96Q15
determination method
IDA
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
determination method
IBA
IDA
IEA
NAS
TAS
7 references
retrieved
8 April 2019
stated in
The human RNA surveillance factor UPF1 is required for S phase progression and genome stability
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
TAS
retrieved
8 April 2019
stated in
Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
IEA
retrieved
8 April 2019
stated in
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q96Q15
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96Q15
determination method
IBA

Identifiers

 
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