Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans (Q21133609)

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English	Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans	scientific article

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27 February 2020

Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans (English)

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27 February 2020

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Kay-Uwe Wagner

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27 February 2020

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Sung O Park

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27 February 2020

Heather L Wamsley

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27 February 2020

Kyungmi Bae

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27 February 2020

Zhongbo Hu

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27 February 2020

Xiaomiao Li

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27 February 2020

Se-woon Choe

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27 February 2020

William B Slayton

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27 February 2020

S Paul Oh

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27 February 2020

Peter P Sayeski

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27 February 2020

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27 March 2013

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27 February 2020

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27 February 2020

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27 February 2020

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27 February 2020

e59675

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27 February 2020

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Creative Commons Attribution 4.0 International

27 March 2013

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April 2022 Public Data File from Crossref

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0 references

Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

1 reference

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19 March 2017

Generalized lacZ expression with the ROSA26 Cre reporter strain

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19 March 2017

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

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19 March 2017

Jak2 is essential for signaling through a variety of cytokine receptors

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19 March 2017

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

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19 March 2017

Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice

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19 March 2017

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

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19 March 2017

A gain-of-function mutation of JAK2 in myeloproliferative disorders

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7 April 2017

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

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7 April 2017

Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

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7 April 2017

Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling

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12 September 2017

JAK inhibitors for myeloproliferative neoplasms: clarifying facts from myths

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12 September 2017

Serious adverse events during ruxolitinib treatment discontinuation in patients with myelofibrosis

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12 September 2017

JAK inhibitors in myeloproliferative neoplasms: rationale, current data and perspective

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12 September 2017

SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies.

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12 September 2017

Critical role of Src-Syk-PLC{gamma}2 signaling in megakaryocyte migration and thrombopoiesis.

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12 September 2017

Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5

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12 September 2017

Heterozygous kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic stem cell function

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12 September 2017

The role of Janus kinases in haemopoiesis and haematological malignancy

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12 September 2017

Lyn kinase promotes erythroblast expansion and late-stage development

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12 September 2017

Identification of an acquired JAK2 mutation in polycythemia vera

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3609865

12 September 2017

Jak2 tyrosine kinase: a true jak of all trades?

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12 September 2017

Critical role for Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development

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12 September 2017

Interplay between the cardiac renin angiotensin system and JAK-STAT signaling: role in cardiac hypertrophy, ischemia/reperfusion dysfunction, and heart failure

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12 September 2017

JAKs, STATs and Src kinases in hematopoiesis

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27 September 2017

Ruxolitinib: the first FDA approved therapy for the treatment of myelofibrosis.

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21 January 2018

Challenges facing JAK inhibitor therapy for myeloproliferative neoplasms.

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21 January 2018

Differential oocyte-specific expression of Cre recombinase activity in GDF-9-iCre, Zp3cre, and Msx2Cre transgenic mice.

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21 January 2018

Increased megakaryocytopoiesis in Lyn-deficient mice

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21 January 2018

Inhibition of JAK2 protects renal endothelial and epithelial cells from oxidative stress and cyclosporin A toxicity

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21 January 2018

The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure.

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A functional Jak2 tyrosine kinase domain is essential for mouse development.

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Bone marrow stromal cell distribution of basic fibroblast growth factor in chronic myeloid disorders

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JAK2, a third member of the JAK family of protein tyrosine kinases

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The Src family of tyrosine protein kinases in hemopoietic signal transduction

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Intrinsic and extrinsic effects of mafG deficiency on hematopoietic recovery following bone marrow transplant

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Long-term outcome of treatment with ruxolitinib in myelofibrosis

1 reference

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based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0059675

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27 February 2020

2013PLoSO...859675P

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release_4zm7nzvnivaydneal7xjlnltje

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https://api.fatcat.wiki/v0/release/4zm7nzvnivaydneal7xjlnltje

24 November 2022

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27 February 2020

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27 February 2020

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