Mitogen-activated protein kinase kinase kinase 10 (Q21133280)

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mammalian protein found in Homo sapiens

MKN28 kinase
MAP3K10
MKN28 derived nonreceptor_type serine/threonine kinase
mitogen-activated protein kinase kinase kinase 10
protein kinase MST
mixed lineage kinase 2

Language	Label	Description	Also known as
English	Mitogen-activated protein kinase kinase kinase 10	mammalian protein found in Homo sapiens	MKN28 kinase MAP3K10 MKN28 derived nonreceptor_type serine/threonine kinase mitogen-activated protein kinase kinase kinase 10 protein kinase MST mixed lineage kinase 2

Statements

1 reference

13 November 2019

UniProt protein ID

SH3-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02779

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02779

mitogen-activated protein (MAP) kinase kinase kinase 10

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02779

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

MLK1-3, SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

protein kinase activity

determination method

4 references

8 April 2019

Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

8 April 2019

Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

bHLH transcription factor binding

determination method

1 reference

8 April 2019

Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

determination method

2 references

protein serine/threonine kinase activity

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

8 April 2019

Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

determination method

1 reference

8 April 2019

Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

biological process

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

positive regulation of JUN kinase activity

determination method

1 reference

8 April 2019

Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

positive regulation of JNK cascade

determination method

1 reference

8 April 2019

Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

negative regulation of DNA-binding transcription factor activity

determination method

1 reference

8 April 2019

Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

protein phosphorylation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

determination method

1 reference

8 April 2019

Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

peptidyl-serine phosphorylation

determination method

1 reference

8 April 2019

Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

protein autophosphorylation

determination method

1 reference

8 April 2019

Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

smoothened signaling pathway

determination method

1 reference

8 April 2019

Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

peptidyl-threonine phosphorylation

determination method

1 reference

8 April 2019

Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

negative regulation of transcription, DNA-templated

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

8 April 2019

Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

signal transduction

determination method

1 reference

8 April 2019

Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

apoptotic process

determination method

1 reference

8 April 2019

Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02779

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02779

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02779

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02779

serine/threonine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02779

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02779

MLK1-3, SH3 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02779

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000253055

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000253055

ENSP00000471116

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000471116

ENSP00000471916

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000471916

ENSP00000473021

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000473021

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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