Mitofusin 1 (Q21133189)

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mammalian protein found in Homo sapiens

mitochondrial transmembrane GTPase FZO-2
MFN1
mitofusin-1
fzo homolog
putative transmembrane GTPase
mitochondrial transmembrane GTPase Fzo-1
transmembrane GTPase MFN1

Language	Label	Description	Also known as
English	Mitofusin 1	mammalian protein found in Homo sapiens	mitochondrial transmembrane GTPase FZO-2 MFN1 mitofusin-1 fzo homolog putative transmembrane GTPase mitochondrial transmembrane GTPase Fzo-1 transmembrane GTPase MFN1

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IWA4

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IWA4

membrane fusion pore

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

membrane proteins

1 reference

based on heuristic

inferred from GOA cell component → membrane

Fzo/mitofusin HR2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

determination method

2 references

protein binding

determination method

1 reference

8 April 2019

Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

GTPase activity

determination method

3 references

21 June 2018

MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWA4&geneProductId=UniProtKB:Q8IWA4

determination method

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWA4&geneProductId=UniProtKB:Q8IWA4

determination method

21 June 2018

Structures of human mitofusin 1 provide insight into mitochondrial tethering

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWA4&geneProductId=UniProtKB:Q8IWA4

determination method

GTPase activity

determination method

4 references

8 April 2019

MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

8 April 2019

Structures of human mitofusin 1 provide insight into mitochondrial tethering

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

8 April 2019

Structures of human mitofusin 1 provide insight into mitochondrial tethering

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

8 April 2019

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

integral component of mitochondrial outer membrane

determination method

1 reference

8 April 2019

Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

outer mitochondrial membrane protein complex

determination method

1 reference

8 April 2019

Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

integral component of membrane

determination method

3 references

intrinsic component of mitochondrial outer membrane

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

biological process

mitochondrial fusion

determination method

6 references

21 June 2018

MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWA4&geneProductId=UniProtKB:Q8IWA4

determination method

21 June 2018

Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWA4&geneProductId=UniProtKB:Q8IWA4

determination method

21 June 2018

Structures of human mitofusin 1 provide insight into mitochondrial tethering

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWA4&geneProductId=UniProtKB:Q8IWA4

determination method

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWA4&geneProductId=UniProtKB:Q8IWA4

determination method

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWA4&geneProductId=UniProtKB:Q8IWA4

determination method

21 June 2018

The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWA4&geneProductId=UniProtKB:Q8IWA4

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

GTP metabolic process

determination method

1 reference

8 April 2019

Structures of human mitofusin 1 provide insight into mitochondrial tethering

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

mitochondrion localization

determination method

1 reference

21 June 2018

Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IWA4&geneProductId=UniProtKB:Q8IWA4

determination method

mitochondrial fusion

determination method

7 references

8 April 2019

MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

8 April 2019

Structures of human mitofusin 1 provide insight into mitochondrial tethering

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

8 April 2019

Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

8 April 2019

The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IWA4

determination method

Fzo/mitofusin HR2 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IWA4

Dynamin-type guanine nucleotide-binding (G) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IWA4

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000349963

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000349963

ENSP00000263969

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000263969

ENSP00000419134

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000419134

ENSP00000419926

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000419926

ENSP00000420148

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000420148

ENSP00000420617

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000420617

PDB structure ID

1 reference

10 November 2015

http://www.uniprot.org/uniprot/Q811U4.txt?version=109

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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